biostudies-literatureUnknown46(1)Schmidt VFUniversitätsklinik München<h4>Purpose</h4>Arteriovenous malformations (AVMs) as rare diseases are diagnostically and therapeutically challenging. Due to the limited evidence regarding treatment outcome, prospective data are needed on how different treatment regimens affect outcome. The aims of this prospective trial are to determine effectiveness, safety, and clinical outcome of multimodal treatment in patients with extracranial AVMs.<h4>Materials and methods</h4>After clinical and magnetic resonance imaging (MRI)-based diagnosis and informed consent, 146 patients (> 4 years and < 70 years) undergoing multimodal therapy in tertiary care vascular anomalies centers will be included in this prospective observational trial. Treatment options include conservative management, medical therapy, minimally invasive image-guiCardiovascular and interventional radiology142-151https://www.ebi.ac.uk/biostudies/studies/S-EPMC9810564biostudies-literatureClinical Outcome and Quality of Life of Multimodal Treatment of Extracranial Arteriovenous Malformations: The APOLLON Study Protocol.PMC9810564Ricke JMukke ASchmid AWildgruber MKimm MAAPOLLON investigatorsZenker MWohlgemuth WASchmidt VFVielsmeier VMasthoff MMeyer LSchinner RCangir OSeidensticker MBrill RKuppers Jda Silva NPBHaberle BSeebauer CTHaubner FLang WSporns PBfalseClinical Outcome and Quality of Life of Multimodal Treatment of Extracranial Arteriovenous Malformations: The APOLLON Study Protocol.<h4>Purpose</h4>Arteriovenous malformations (AVMs) as rare diseases are diagnostically and therapeutically challenging. Due to the limited evidence regarding treatment outcome, prospective data are needed on how different treatment regimens affect outcome. The aims of this prospective trial are to determine effectiveness, safety, and clinical outcome of multimodal treatment in patients with extracranial AVMs.<h4>Materials and methods</h4>After clinical and magnetic resonance imaging (MRI)-based diagnosis and informed consent, 146 patients (> 4 years and < 70 years) undergoing multimodal therapy in tertiary care vascular anomalies centers will be included in this prospective observational trial. Treatment options include conservative management, medical therapy, minimally invasive image-gui2023-01-01T00:00:00Z2023 Jan2025-04-04T10:58:59.662Z2025-02-19T03:30:37.053ZS-EPMC98105643626150710.1007/s00270-022-03296-8