{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Niu X"],"funding":["Japan Society for the Promotion of Science"],"pagination":["1048957"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9811314"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["The RNA-directed DNA methylation (RdDM) pathway plays an essential role in the transposon silencing mechanism; the DDR complex, consisting of DRD1, DMS3, and RDM1, is an essential component of the RdDM pathway. <i>ONSEN</i>, identified in <i>Arabidopsis</i>, is a retrotransposon activated by heat stress at 37°C; however, studies on the regulation of <i>ONSEN</i> are limited. In this study, we analyzed the regulation of <i>ONSEN</i> activity by the DDR complex in <i>Arabidopsis</i>. We elucidated that loss of any component of the DDR complex increased <i>ONSEN</i> transcript levels. Transgenerational transposition of <i>ONSEN</i> was observed in the DDR-complex mutants treated with heat stress for 48 h. Furthermore, the DDR complex components DRD1, DMS3, and RDM1 played independent roles in"],"journal":["Frontiers in plant science"],"pubmed_title":["Regulatory mechanism of a heat-activated retrotransposon by DDR complex in <i>Arabidopsis thaliana</i>."],"pmcid":["PMC9811314"],"funding_grant_id":["JP21K06008"],"pubmed_authors":["Chen L","Ito H","Kato A","Niu X"],"additional_accession":[]},"is_claimable":false,"name":"Regulatory mechanism of a heat-activated retrotransposon by DDR complex in <i>Arabidopsis thaliana</i>.","description":"The RNA-directed DNA methylation (RdDM) pathway plays an essential role in the transposon silencing mechanism; the DDR complex, consisting of DRD1, DMS3, and RDM1, is an essential component of the RdDM pathway. <i>ONSEN</i>, identified in <i>Arabidopsis</i>, is a retrotransposon activated by heat stress at 37°C; however, studies on the regulation of <i>ONSEN</i> are limited. In this study, we analyzed the regulation of <i>ONSEN</i> activity by the DDR complex in <i>Arabidopsis</i>. We elucidated that loss of any component of the DDR complex increased <i>ONSEN</i> transcript levels. Transgenerational transposition of <i>ONSEN</i> was observed in the DDR-complex mutants treated with heat stress for 48 h. Furthermore, the DDR complex components DRD1, DMS3, and RDM1 played independent roles in","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-14T20:13:02.896Z","creation":"2024-11-20T08:57:13.359Z"},"accession":"S-EPMC9811314","cross_references":{"pubmed":["36618621"],"doi":["10.3389/fpls.2022.1048957"]}}