biostudies-literatureNatsume HSmoking Research FoundationAMEDJapan Society for the Promotion of Science, KAKENHIJapan Society for the Promotion of Science1https://www.ebi.ac.uk/biostudies/studies/S-EPMC9811704biostudies-literatureUnknown45(1)<h4>Aim</h4>Mutation spectrum of TP53 in gastric cancer (GC) has been investigated world-widely, but a comparison of mutation spectrum among GCs from various regions in the world are still sparsely documented. In order to identify the difference of TP53 mutation spectrum in GCs in Eastern Europe and in East Asia, we sequenced TP53 in GCs from Eastern Europe, Lujiang (China), and Yokohama, Kanagawa (Japan) and identified the feature of TP53 mutations of GC in these regions.<h4>Subjects and method</h4>In total, 689 tissue samples of GC were analyzed: 288 samples from East European populations (25 from Hungary, 71 from Poland and 192 from Romania), 268 from Yokohama, Kanagawa, Japan and 133 from Lujiang, Anhui province, China. DNA was extracted from FFPE tissue of Chinese, East European casesGenes and environment : the official journal of the Japanese Environmental Mutagen SocietyNon-CpG sites preference in G:C > A:T transition of TP53 in gastric cancer of Eastern Europe (Poland, Romania and Hungary) compared to East Asian countries (China and Japan).PMC9811704JP26670187JP22659072JP20ck0106545JP24659161JP19ck0106264Matsuda TGuo WNzitakera AOshima TIwashita YSekiyama AGurzu SSzczepaniak KManirakiza FWang YGedek MWu YIshino KOhta TSugimura HYamada HHe QSuto JKadar ZXiao NTsuburaya ASzekely TMiyagi YYoshikawa TCai ZKasajima RNatsume HKurono NfalseNon-CpG sites preference in G:C > A:T transition of TP53 in gastric cancer of Eastern Europe (Poland, Romania and Hungary) compared to East Asian countries (China and Japan).<h4>Aim</h4>Mutation spectrum of TP53 in gastric cancer (GC) has been investigated world-widely, but a comparison of mutation spectrum among GCs from various regions in the world are still sparsely documented. In order to identify the difference of TP53 mutation spectrum in GCs in Eastern Europe and in East Asia, we sequenced TP53 in GCs from Eastern Europe, Lujiang (China), and Yokohama, Kanagawa (Japan) and identified the feature of TP53 mutations of GC in these regions.<h4>Subjects and method</h4>In total, 689 tissue samples of GC were analyzed: 288 samples from East European populations (25 from Hungary, 71 from Poland and 192 from Romania), 268 from Yokohama, Kanagawa, Japan and 133 from Lujiang, Anhui province, China. DNA was extracted from FFPE tissue of Chinese, East European cases2023-01-01T00:00:00Z2023 Jan2025-04-04T13:53:27.745Z2025-02-19T03:31:04.229ZS-EPMC98117043660031510.1186/s41021-022-00257-y