{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Zhu N"],"pubmed_abstract":["<b>Background:</b> Interleukin-6 (IL-6)/soluble IL-6 receptor (sIL-6R) promotes peritoneal angiogenesis by stimulating SP4-mediated vascular endothelial growth factor (VEGF) production in peritoneal dialysis (PD). Moreover, histone methyltransferase enhancer of zeste homologue 2 (EZH2) is involved in IL-6/sIL-6R signalling via the acceleration of vascular endothelial growth factor (VEGF)-induced angiogenesis. However, the molecular mechanism underlying how EZH2 epigenetically activates VFGF expression in IL-6/sIL-6R signalling during PD is still unclear. <b>Methods and Results:</b> In this study, we measured the expression of EZH2, DNMT3B and SP4 in human peritoneal mesothelial cells (HPMCs) treated with IL-6/sIL-6R stimulation and/or EZH2 overexpression, silencing or inhibition. Methylati"],"journal":["International journal of medical sciences"],"pagination":["114-124"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9812808"],"repository":["biostudies-literature"],"pubmed_title":["EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway."],"pmcid":["PMC9812808"],"pubmed_authors":["Zhu N","Guan H","Zhang Y","Gu L","Wang X","Yuan W","Jia J","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"EZH2 promotes angiogenesis in peritoneal dialysis by epigenetically activating SP4 expression in the IL-6/sIL-6R signalling pathway.","description":"<b>Background:</b> Interleukin-6 (IL-6)/soluble IL-6 receptor (sIL-6R) promotes peritoneal angiogenesis by stimulating SP4-mediated vascular endothelial growth factor (VEGF) production in peritoneal dialysis (PD). Moreover, histone methyltransferase enhancer of zeste homologue 2 (EZH2) is involved in IL-6/sIL-6R signalling via the acceleration of vascular endothelial growth factor (VEGF)-induced angiogenesis. However, the molecular mechanism underlying how EZH2 epigenetically activates VFGF expression in IL-6/sIL-6R signalling during PD is still unclear. <b>Methods and Results:</b> In this study, we measured the expression of EZH2, DNMT3B and SP4 in human peritoneal mesothelial cells (HPMCs) treated with IL-6/sIL-6R stimulation and/or EZH2 overexpression, silencing or inhibition. Methylati","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T12:37:35.886Z","creation":"2025-04-04T12:37:35.886Z"},"accession":"S-EPMC9812808","cross_references":{"pubmed":["36619221"],"doi":["10.7150/ijms.78428"]}}