biostudies-literatureSannaa WNIDDK NIH HHSNational Institutes of Health377-386https://www.ebi.ac.uk/biostudies/studies/S-EPMC9812862biostudies-literatureUnknown25(2)<h4>Aim</h4>To identify patient factors, including gastrointestinal functions, that are predictive or associated with weight loss in response to once-daily 3 mg liraglutide administered subcutaneously (SQ) or placebo in obesity.<h4>Methods</h4>One hundred and thirty-six obese adults (87% female) were randomized in a placebo-controlled, 16-week trial of liraglutide, escalated to 3 mg administered SQ daily. Gastrointestinal functions were measured at baseline and 16 weeks: gastric emptying of solids (GET_1/2 ); fasting and postprandial gastric volumes; kcal ingested during ad libitum buffet meal and the nutrient drink test. GET_1/2 was also measured at 5 weeks. A multiple variable regression model examined variables associated with weight loss of more than 4 kg at 16 weekDiabetes, obesity & metabolismFactors associated with successful weight loss after liraglutide treatment for obesity.PMC9812862R01‐DK67071R01 DK067071Dilmaghani SCamilleri MMaselli DHarmsen WSBouSaba JSannaa WEckert DTaylor ALAtieh JAcosta AfalseFactors associated with successful weight loss after liraglutide treatment for obesity.<h4>Aim</h4>To identify patient factors, including gastrointestinal functions, that are predictive or associated with weight loss in response to once-daily 3 mg liraglutide administered subcutaneously (SQ) or placebo in obesity.<h4>Methods</h4>One hundred and thirty-six obese adults (87% female) were randomized in a placebo-controlled, 16-week trial of liraglutide, escalated to 3 mg administered SQ daily. Gastrointestinal functions were measured at baseline and 16 weeks: gastric emptying of solids (GET_1/2 ); fasting and postprandial gastric volumes; kcal ingested during ad libitum buffet meal and the nutrient drink test. GET_1/2 was also measured at 5 weeks. A multiple variable regression model examined variables associated with weight loss of more than 4 kg at 16 week2023-01-01T00:00:00Z2023 Feb2025-04-26T11:53:46.86Z2025-02-19T04:59:43.509ZS-EPMC98128623619371310.1111/dom.14880