{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fan F"],"funding":["Beijing Municipal Natural Science Foundation","NIMH NIH HHS","National Natural Science Foundation of China","Beijing Hospitals Authority Youth Programme","Capital's Funds for Health Improvement and Research","Cultivation Program of Beijing Municipal Hospital Administration","National Institute of Health grant","NIH HHS"],"pagination":["12-19"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9812867"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(1)"],"pubmed_abstract":["<h4>Aim</h4>Approximately a third of patients with schizophrenia fail to adequately respond to antipsychotic medications, a condition known as treatment resistance (TR). We aimed to assess cognitive and cortical thickness deficits and their relationship to TR in schizophrenia.<h4>Method</h4>We recruited patients with schizophrenia (n = 127), including patients at treatment initiation (n = 45), treatment-responsive patients (n = 40) and TR patients (n = 42), and healthy controls (n = 83). Clinical symptoms, neurocognitive function, and structural images were assessed. We performed group comparisons, and explored association of cortical thickness and cognition with TR.<h4>Results</h4>The TR patients showed significantly more severe clinical symptoms and cognitive impairment relative to the t"],"journal":["Psychiatry and clinical neurosciences"],"pubmed_title":["Association of cortical thickness and cognition with schizophrenia treatment resistance."],"pmcid":["PMC9812867"],"funding_grant_id":["PX2018069","2018-4-2133","31671145","S10 OD023696","QML20202001","81401115","81761128021","RF1 MH123163","R01MH112180","R01 MH112180","7182074"],"pubmed_authors":["Li H","Huang J","Tian B","Du X","Yang F","Kochunov P","Fan F","Hong LE","Li Y","Hare S","Tan Y","Tan S","Chen S","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Association of cortical thickness and cognition with schizophrenia treatment resistance.","description":"<h4>Aim</h4>Approximately a third of patients with schizophrenia fail to adequately respond to antipsychotic medications, a condition known as treatment resistance (TR). We aimed to assess cognitive and cortical thickness deficits and their relationship to TR in schizophrenia.<h4>Method</h4>We recruited patients with schizophrenia (n = 127), including patients at treatment initiation (n = 45), treatment-responsive patients (n = 40) and TR patients (n = 42), and healthy controls (n = 83). Clinical symptoms, neurocognitive function, and structural images were assessed. We performed group comparisons, and explored association of cortical thickness and cognition with TR.<h4>Results</h4>The TR patients showed significantly more severe clinical symptoms and cognitive impairment relative to the t","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-26T07:45:42.698Z","creation":"2025-04-06T12:28:38.983Z"},"accession":"S-EPMC9812867","cross_references":{"pubmed":["36184782"],"doi":["10.1111/pcn.13486"]}}