{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jianyi D"],"funding":["National Science Foundation of China"],"pagination":["73-85"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9813028"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(1)"],"pubmed_abstract":["Immunosuppression induced by myeloid-derived suppressor cells (MDSCs) is one of the main obstacles to the efficacy of immunotherapy for cervical cancer. Recent studies on the immunosuppressive ability of MDSCs have primarily focused on T cells, but the effect of MDSCs on B cells function is still unclear. In a study of clinical specimens, we found that the accumulation of MDSCs in patients with cervical cancer was accompanied by high expression of B cell activating factor (BAFF) on the surface and high expression of interleukin (IL)-10-producing B cells (B10) in vivo. We found that the absence of BAFF could significantly inhibit tumor growth in a cervical cancer model using BAFF KO mice. Further studies showed that abundant MDSCs in cervical cancer induced B cells to differentiate into B10"],"journal":["Cancer immunology, immunotherapy : CII"],"pubmed_title":["Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF/BAFF-R pathway to promote immunosuppression in cervical cancer."],"pmcid":["PMC9813028"],"funding_grant_id":["81572546","81871167","81771529"],"pubmed_authors":["Jianyi D","Qingliang Z","Haili G","Lingfei H","Baoyou H","Meiqin Y","Bo Y","Fang L","Haoran H"],"additional_accession":[]},"is_claimable":false,"name":"Myeloid-derived suppressor cells cross-talk with B10 cells by BAFF/BAFF-R pathway to promote immunosuppression in cervical cancer.","description":"Immunosuppression induced by myeloid-derived suppressor cells (MDSCs) is one of the main obstacles to the efficacy of immunotherapy for cervical cancer. Recent studies on the immunosuppressive ability of MDSCs have primarily focused on T cells, but the effect of MDSCs on B cells function is still unclear. In a study of clinical specimens, we found that the accumulation of MDSCs in patients with cervical cancer was accompanied by high expression of B cell activating factor (BAFF) on the surface and high expression of interleukin (IL)-10-producing B cells (B10) in vivo. We found that the absence of BAFF could significantly inhibit tumor growth in a cervical cancer model using BAFF KO mice. Further studies showed that abundant MDSCs in cervical cancer induced B cells to differentiate into B10","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-04T11:35:35.895Z","creation":"2025-04-04T11:35:35.895Z"},"accession":"S-EPMC9813028","cross_references":{"pubmed":["35725835"],"doi":["10.1007/s00262-022-03226-0"]}}