{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["36(1)"],"submitter":["Yuan L"],"funding":["The project was supported by Starting Research Funding from Xinxiang Medical University"],"pubmed_abstract":["Estrogen receptor α (ERα) is the most common clinical marker used for breast cancer prognosis and the classification of breast cancer subtypes. Clinically, patients with estrogen receptor-positive breast cancer can receive endocrine therapy. However, resistance to endocrine therapy has become an urgent clinical problem. A large number of previous studies have proven that posttranslational modification of the estrogen receptor is significantly related to endocrine therapy resistance. RNF2 is a member of the RING finger protein family that functions as an E3 ubiquitin ligase. Several studies have clarified that RNF2 is a critical regulator of ERα transcriptional regulation. In our current study, we identified RNF2 as an important posttranslational modification regulator of the estrogen recep"],"journal":["Human cell"],"pagination":["353-365"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9813066"],"repository":["biostudies-literature"],"pubmed_title":["The ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression."],"pmcid":["PMC9813066"],"pubmed_authors":["Yang H","Li X","Li H","Yuan L"],"additional_accession":[]},"is_claimable":false,"name":"The ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression.","description":"Estrogen receptor α (ERα) is the most common clinical marker used for breast cancer prognosis and the classification of breast cancer subtypes. Clinically, patients with estrogen receptor-positive breast cancer can receive endocrine therapy. However, resistance to endocrine therapy has become an urgent clinical problem. A large number of previous studies have proven that posttranslational modification of the estrogen receptor is significantly related to endocrine therapy resistance. RNF2 is a member of the RING finger protein family that functions as an E3 ubiquitin ligase. Several studies have clarified that RNF2 is a critical regulator of ERα transcriptional regulation. In our current study, we identified RNF2 as an important posttranslational modification regulator of the estrogen recep","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-04-30T12:56:56.825Z","creation":"2025-04-06T14:10:31.041Z"},"accession":"S-EPMC9813066","cross_references":{"pubmed":["36271315"],"doi":["10.1007/s13577-022-00810-5"]}}