biostudies-literatureUnknown36(1)Yuan LThe project was supported by Starting Research Funding from Xinxiang Medical UniversityEstrogen receptor α (ERα) is the most common clinical marker used for breast cancer prognosis and the classification of breast cancer subtypes. Clinically, patients with estrogen receptor-positive breast cancer can receive endocrine therapy. However, resistance to endocrine therapy has become an urgent clinical problem. A large number of previous studies have proven that posttranslational modification of the estrogen receptor is significantly related to endocrine therapy resistance. RNF2 is a member of the RING finger protein family that functions as an E3 ubiquitin ligase. Several studies have clarified that RNF2 is a critical regulator of ERα transcriptional regulation. In our current study, we identified RNF2 as an important posttranslational modification regulator of the estrogen recepHuman cell353-365https://www.ebi.ac.uk/biostudies/studies/S-EPMC9813066biostudies-literatureThe ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression.PMC9813066Yang HLi XLi HYuan LfalseThe ubiquitin ligase RNF2 stabilizes ERα and modulates breast cancer progression.Estrogen receptor α (ERα) is the most common clinical marker used for breast cancer prognosis and the classification of breast cancer subtypes. Clinically, patients with estrogen receptor-positive breast cancer can receive endocrine therapy. However, resistance to endocrine therapy has become an urgent clinical problem. A large number of previous studies have proven that posttranslational modification of the estrogen receptor is significantly related to endocrine therapy resistance. RNF2 is a member of the RING finger protein family that functions as an E3 ubiquitin ligase. Several studies have clarified that RNF2 is a critical regulator of ERα transcriptional regulation. In our current study, we identified RNF2 as an important posttranslational modification regulator of the estrogen recep2023-01-01T00:00:00Z2023 Jan2026-04-30T12:56:56.825Z2025-04-06T14:10:31.041ZS-EPMC98130663627131510.1007/s13577-022-00810-5