{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Frentzel S"],"funding":["Deutsche Forschungsgemeinschaft"],"pubmed_abstract":["IκB proteins regulate the inhibition and activation of NF-κB transcription factor complexes. While classical IκB proteins keep NF-κB complexes inactive in the cytoplasm, atypical IκB proteins act on activated NF-κB complexes located in the nucleus. Most of the knowledge regarding the function of IκB proteins has been collected <i>in vitro</i>, while far less is known regarding their impact on activation and regulation of immune responses during <i>in vivo</i> infections. Combining <i>in vivo Listeria monocytogenes</i> (Lm) infection with comparative <i>ex vivo</i> transcriptional profiling of the hepatic response to the pathogen we observed that in contrast to wild type mice that mounted a robust inflammatory response, IκB<sub>NS</sub>-deficiency was generally associated with a transcripti"],"journal":["Frontiers in immunology"],"pagination":["1028789"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9813228"],"repository":["biostudies-literature"],"pubmed_title":["IκB<sub>NS</sub>-deficiency protects mice from fatal <i>Listeria monocytogenes</i> infection by blunting pro-inflammatory signature in Ly6C<sup>high</sup> monocytes and preventing exaggerated innate immune responses."],"pmcid":["PMC9813228"],"pubmed_authors":["Jeron A","Pausder A","Volckmar J","Schmitz I","Bruder D","Kershaw O","Frentzel S"],"additional_accession":[]},"is_claimable":false,"name":"IκB<sub>NS</sub>-deficiency protects mice from fatal <i>Listeria monocytogenes</i> infection by blunting pro-inflammatory signature in Ly6C<sup>high</sup> monocytes and preventing exaggerated innate immune responses.","description":"IκB proteins regulate the inhibition and activation of NF-κB transcription factor complexes. While classical IκB proteins keep NF-κB complexes inactive in the cytoplasm, atypical IκB proteins act on activated NF-κB complexes located in the nucleus. Most of the knowledge regarding the function of IκB proteins has been collected <i>in vitro</i>, while far less is known regarding their impact on activation and regulation of immune responses during <i>in vivo</i> infections. Combining <i>in vivo Listeria monocytogenes</i> (Lm) infection with comparative <i>ex vivo</i> transcriptional profiling of the hepatic response to the pathogen we observed that in contrast to wild type mice that mounted a robust inflammatory response, IκB<sub>NS</sub>-deficiency was generally associated with a transcripti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-07T17:33:19.802Z","creation":"2025-04-06T00:52:50.606Z"},"accession":"S-EPMC9813228","cross_references":{"pubmed":["36618344"],"doi":["10.3389/fimmu.2022.1028789"]}}