{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Zhang Z"],"pubmed_abstract":["<i>Mycoplasma pneumoniae</i> (MP) is an important human pathogen that mainly affects children causing general and severe <i>Mycoplasma pneumoniae</i> pneumonia (G/SMPP). In the present study, a comprehensive immune response data (33 cytokines) was obtained in school-age children (3-9 years old) during MPP, aiming to analyze the immune response patterns during MPP. At acute phase, changes of cytokines were both detected in GMPP (24/33) and SMPP (23/33) groups compared to the healthy group (p < 0.05), with 20 identical cytokines. Between MPP groups, the levels of 13 cytokines (IL-2, IL-10, IL-11, IL-12, IL-20, IL-28A, IL-32, IL-35, IFN-α2, IFN-γ, IFN-β, BAFF, and TSLP) were higher and three cytokines (LIGHT, OPN and CHI3L1) were lower in the SMPP group than in the GMPP group (p < 0.05). Func"],"journal":["Frontiers in immunology"],"pagination":["1088725"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9813340"],"repository":["biostudies-literature"],"pubmed_title":["Serum cytokine profiling reveals different immune response patterns during general and severe <i>Mycoplasma pneumoniae</i> pneumonia."],"pmcid":["PMC9813340"],"pubmed_authors":["Dou H","Wan R","Li J","Dong Y","Jia C","Wang D","Xin D","Wei R","Zhang Z","Ning L","Tu P","Xu B","Shi D"],"additional_accession":[]},"is_claimable":false,"name":"Serum cytokine profiling reveals different immune response patterns during general and severe <i>Mycoplasma pneumoniae</i> pneumonia.","description":"<i>Mycoplasma pneumoniae</i> (MP) is an important human pathogen that mainly affects children causing general and severe <i>Mycoplasma pneumoniae</i> pneumonia (G/SMPP). In the present study, a comprehensive immune response data (33 cytokines) was obtained in school-age children (3-9 years old) during MPP, aiming to analyze the immune response patterns during MPP. At acute phase, changes of cytokines were both detected in GMPP (24/33) and SMPP (23/33) groups compared to the healthy group (p < 0.05), with 20 identical cytokines. Between MPP groups, the levels of 13 cytokines (IL-2, IL-10, IL-11, IL-12, IL-20, IL-28A, IL-32, IL-35, IFN-α2, IFN-γ, IFN-β, BAFF, and TSLP) were higher and three cytokines (LIGHT, OPN and CHI3L1) were lower in the SMPP group than in the GMPP group (p < 0.05). Func","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-03T16:47:55.382Z","creation":"2025-04-04T13:52:55.104Z"},"accession":"S-EPMC9813340","cross_references":{"pubmed":["36618370"],"doi":["10.3389/fimmu.2022.1088725"]}}