biostudies-literatureUnknown13Zhang Z<i>Mycoplasma pneumoniae</i> (MP) is an important human pathogen that mainly affects children causing general and severe <i>Mycoplasma pneumoniae</i> pneumonia (G/SMPP). In the present study, a comprehensive immune response data (33 cytokines) was obtained in school-age children (3-9 years old) during MPP, aiming to analyze the immune response patterns during MPP. At acute phase, changes of cytokines were both detected in GMPP (24/33) and SMPP (23/33) groups compared to the healthy group (p < 0.05), with 20 identical cytokines. Between MPP groups, the levels of 13 cytokines (IL-2, IL-10, IL-11, IL-12, IL-20, IL-28A, IL-32, IL-35, IFN-α2, IFN-γ, IFN-β, BAFF, and TSLP) were higher and three cytokines (LIGHT, OPN and CHI3L1) were lower in the SMPP group than in the GMPP group (p < 0.05). FuncFrontiers in immunology1088725https://www.ebi.ac.uk/biostudies/studies/S-EPMC9813340biostudies-literatureSerum cytokine profiling reveals different immune response patterns during general and severe <i>Mycoplasma pneumoniae</i> pneumonia.PMC9813340Dou HWan RLi JDong YJia CWang DXin DWei RZhang ZNing LTu PXu BShi DfalseSerum cytokine profiling reveals different immune response patterns during general and severe <i>Mycoplasma pneumoniae</i> pneumonia.<i>Mycoplasma pneumoniae</i> (MP) is an important human pathogen that mainly affects children causing general and severe <i>Mycoplasma pneumoniae</i> pneumonia (G/SMPP). In the present study, a comprehensive immune response data (33 cytokines) was obtained in school-age children (3-9 years old) during MPP, aiming to analyze the immune response patterns during MPP. At acute phase, changes of cytokines were both detected in GMPP (24/33) and SMPP (23/33) groups compared to the healthy group (p < 0.05), with 20 identical cytokines. Between MPP groups, the levels of 13 cytokines (IL-2, IL-10, IL-11, IL-12, IL-20, IL-28A, IL-32, IL-35, IFN-α2, IFN-γ, IFN-β, BAFF, and TSLP) were higher and three cytokines (LIGHT, OPN and CHI3L1) were lower in the SMPP group than in the GMPP group (p < 0.05). Func2022-01-01T00:00:00Z20222026-06-03T16:47:55.382Z2025-04-04T13:52:55.104ZS-EPMC98133403661837010.3389/fimmu.2022.1088725