biostudies-literatureSilins IAkademiska SjukhusetUppsala UniversityMedical Research CouncilMedical Research Council of the United Kingdom398-409https://www.ebi.ac.uk/biostudies/studies/S-EPMC9816205biostudies-literatureUnknown50(2)<h4>Purpose</h4>[¹¹C]Metomidate positron emission tomography (PET) is currently used for staging of adrenocortical carcinoma and for lateralization in primary aldosteronism (PA). Due to the short half-life of carbon-11 and a high non-specific liver uptake of [¹¹C]metomidate there is a need for improved adrenal imaging methods. In a previous pre-clinical study para-chloro-2-[¹⁸F]fluoroethyletomidate has been proven to be a specific adrenal tracer. The objective is to perform a first evaluation of para-chloro-2-[¹⁸F]fluoroethyletomidate positron emission computed tomography ([¹⁸F]CETO-PET/CT) in patients with adrenal tumours and healthy volunteers.<h4>Methods</h4>Fifteen patients underwent [¹⁸F]CETO-PET/CT. Five healthy voluntEuropean journal of nuclear medicine and molecular imagingFirst-in-human evaluation of [&lt;sup&gt;18&lt;/sup&gt;F]CETO: a novel tracer for adrenocortical tumours.PMC9816205MR/P01710X/1Antoni GBrown MWall AAigbirhio FSilins ILubberink MO'Sullivan LGurnell MRoslin SSundin AHellman PAkerstrom TfalseFirst-in-human evaluation of [&lt;sup&gt;18&lt;/sup&gt;F]CETO: a novel tracer for adrenocortical tumours.<h4>Purpose</h4>[¹¹C]Metomidate positron emission tomography (PET) is currently used for staging of adrenocortical carcinoma and for lateralization in primary aldosteronism (PA). Due to the short half-life of carbon-11 and a high non-specific liver uptake of [¹¹C]metomidate there is a need for improved adrenal imaging methods. In a previous pre-clinical study para-chloro-2-[¹⁸F]fluoroethyletomidate has been proven to be a specific adrenal tracer. The objective is to perform a first evaluation of para-chloro-2-[¹⁸F]fluoroethyletomidate positron emission computed tomography ([¹⁸F]CETO-PET/CT) in patients with adrenal tumours and healthy volunteers.<h4>Methods</h4>Fifteen patients underwent [¹⁸F]CETO-PET/CT. Five healthy volunt2023-01-01T00:00:00Z2023 Jan2026-05-27T23:14:52.48Z2024-12-04T12:40:47.955ZS-EPMC98162053607415710.1007/s00259-022-05957-9