biostudies-literatureXu JGuang Dong Basic and Applied Basic Research FoundationHospital Pharmaceutical Research Fund of Guangdong ProvinceNatural Science Foundation of Guangdong Province18https://www.ebi.ac.uk/biostudies/studies/S-EPMC9817333biostudies-literatureUnknown23(1)<h4>Background</h4>SET domain containing 6 (SETD6) has been shown to be upregulated in multiple human cancers and can promote malignant cell survival. However, expression and function of SETD6 in lung adenocarcinoma (LUAD) remains unaddressed. This study aimed to demonstrate the expression pattern, biological roles and potential mechanisms by which SETD6 dysregulation is associated with LUAD.<h4>Methods</h4>The expression level of SETD6 was evaluated in LUAD clinical specimens and its correlation with clinical parameters were analyzed. In vitro, gain-of-function and loss-of-function experiments were performed to evaluate the effects of SETD6 on cell proliferation, apoptosis, migration, and colony formation of LUAD cell line A549. Western-blot was performed to investigate the involvement ofBMC cancerInvestigating the functional role of SETD6 in lung adenocarcinoma.PMC98173332019A15150120272020A202021A15152201652018A030313138Luo ZChen JLiu MZhou HXu JfalseInvestigating the functional role of SETD6 in lung adenocarcinoma.<h4>Background</h4>SET domain containing 6 (SETD6) has been shown to be upregulated in multiple human cancers and can promote malignant cell survival. However, expression and function of SETD6 in lung adenocarcinoma (LUAD) remains unaddressed. This study aimed to demonstrate the expression pattern, biological roles and potential mechanisms by which SETD6 dysregulation is associated with LUAD.<h4>Methods</h4>The expression level of SETD6 was evaluated in LUAD clinical specimens and its correlation with clinical parameters were analyzed. In vitro, gain-of-function and loss-of-function experiments were performed to evaluate the effects of SETD6 on cell proliferation, apoptosis, migration, and colony formation of LUAD cell line A549. Western-blot was performed to investigate the involvement of2023-01-01T00:00:00Z2023 Jan2025-04-26T06:00:32.745Z2024-11-21T06:23:42.786ZS-EPMC98173333660464210.1186/s12885-022-10476-9