{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["21(1)"],"submitter":["Zhang Z"],"pubmed_abstract":["<h4>Background</h4>Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death worldwide. Plant homeodomain (PHD)-finger domain protein PHF5A has been demonstrated to play a promoting role in a variety of cancers. This study aimed to clarify the role of PHF5A in the progression of GC and its potential mechanism of action.<h4>Methods</h4>Immunohistochemical staining experiments were performed based on tissues from clinical GC patients to reveal PHF5A expression. A series of functional experiments in vitro and in vivo were used to clarify the role of PHF5A in GC.<h4>Results</h4>Clinically, PHF5A was abundantly expressed in GC and existed clinical value indicating poor prognosis. In addition, GC cells with knockdown of PHF5A expression showed slowed pro"],"journal":["Journal of translational medicine"],"pagination":["5"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9817416"],"repository":["biostudies-literature"],"pubmed_title":["PHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS."],"pmcid":["PMC9817416"],"pubmed_authors":["Hua Y","Yang W","Zhang Z","Li B","Peng L","Luo S"],"additional_accession":[]},"is_claimable":false,"name":"PHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS.","description":"<h4>Background</h4>Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death worldwide. Plant homeodomain (PHD)-finger domain protein PHF5A has been demonstrated to play a promoting role in a variety of cancers. This study aimed to clarify the role of PHF5A in the progression of GC and its potential mechanism of action.<h4>Methods</h4>Immunohistochemical staining experiments were performed based on tissues from clinical GC patients to reveal PHF5A expression. A series of functional experiments in vitro and in vivo were used to clarify the role of PHF5A in GC.<h4>Results</h4>Clinically, PHF5A was abundantly expressed in GC and existed clinical value indicating poor prognosis. In addition, GC cells with knockdown of PHF5A expression showed slowed pro","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-26T06:01:21.522Z","creation":"2025-04-06T11:42:44.683Z"},"accession":"S-EPMC9817416","cross_references":{"pubmed":["36609277"],"doi":["10.1186/s12967-022-03821-w"]}}