biostudies-literatureUnknown21(1)Zhang Z<h4>Background</h4>Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death worldwide. Plant homeodomain (PHD)-finger domain protein PHF5A has been demonstrated to play a promoting role in a variety of cancers. This study aimed to clarify the role of PHF5A in the progression of GC and its potential mechanism of action.<h4>Methods</h4>Immunohistochemical staining experiments were performed based on tissues from clinical GC patients to reveal PHF5A expression. A series of functional experiments in vitro and in vivo were used to clarify the role of PHF5A in GC.<h4>Results</h4>Clinically, PHF5A was abundantly expressed in GC and existed clinical value indicating poor prognosis. In addition, GC cells with knockdown of PHF5A expression showed slowed proJournal of translational medicine5https://www.ebi.ac.uk/biostudies/studies/S-EPMC9817416biostudies-literaturePHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS.PMC9817416Hua YYang WZhang ZLi BPeng LLuo SfalsePHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS.<h4>Background</h4>Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death worldwide. Plant homeodomain (PHD)-finger domain protein PHF5A has been demonstrated to play a promoting role in a variety of cancers. This study aimed to clarify the role of PHF5A in the progression of GC and its potential mechanism of action.<h4>Methods</h4>Immunohistochemical staining experiments were performed based on tissues from clinical GC patients to reveal PHF5A expression. A series of functional experiments in vitro and in vivo were used to clarify the role of PHF5A in GC.<h4>Results</h4>Clinically, PHF5A was abundantly expressed in GC and existed clinical value indicating poor prognosis. In addition, GC cells with knockdown of PHF5A expression showed slowed pro2023-01-01T00:00:00Z2023 Jan2025-04-26T06:01:21.522Z2025-04-06T11:42:44.683ZS-EPMC98174163660927710.1186/s12967-022-03821-w