{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Savijoki K"],"funding":["Jane and Aatos Erkko Foundation","Academy of Finland","Novo Nordisk Foundation"],"pagination":["90"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9818890"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Disrupting bacterial quorum sensing (QS) signaling is a promising strategy to combat pathogenic biofilms without the development of antibiotic resistance. Here, we report that food-associated bacteria can interfere with the biofilm formation of a Gram-negative pathogenic bacterium by targeting its AHL (acyl-homoserine lactone) QS system. This was demonstrated by screening metabolic end-products of different lactobacilli and propionibacteria using Gram-negative and biofilm-forming <i>Chromobacterium violaceum</i> as the QS reporter and our anti-QS microscale screening platform with necessary modifications. The method was optimized in terms of the inoculation technique and the concentrations of D-glucose and L-tryptophan, two key factors controlling the synthesis of violacein, a purple pigme"],"journal":["Foods (Basel, Switzerland)"],"pubmed_title":["Food-Grade Bacteria Combat Pathogens by Blocking AHL-Mediated Quorum Sensing and Biofilm Formation."],"pmcid":["PMC9818890"],"funding_grant_id":["348973","322012","NNF20OC0065096","2017-19","325784"],"pubmed_authors":["Sillanpaa A","Yli-Kauhaluoma J","Fallarero A","Varmanen P","San-Martin-Galindo P","Savijoki K","Pitkanen K","van der Velde C","Patel JZ","Parikka M","Edelmann M","Miettinen I"],"additional_accession":[]},"is_claimable":false,"name":"Food-Grade Bacteria Combat Pathogens by Blocking AHL-Mediated Quorum Sensing and Biofilm Formation.","description":"Disrupting bacterial quorum sensing (QS) signaling is a promising strategy to combat pathogenic biofilms without the development of antibiotic resistance. Here, we report that food-associated bacteria can interfere with the biofilm formation of a Gram-negative pathogenic bacterium by targeting its AHL (acyl-homoserine lactone) QS system. This was demonstrated by screening metabolic end-products of different lactobacilli and propionibacteria using Gram-negative and biofilm-forming <i>Chromobacterium violaceum</i> as the QS reporter and our anti-QS microscale screening platform with necessary modifications. The method was optimized in terms of the inoculation technique and the concentrations of D-glucose and L-tryptophan, two key factors controlling the synthesis of violacein, a purple pigme","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-21T16:18:04.099Z","creation":"2025-04-21T16:18:04.099Z"},"accession":"S-EPMC9818890","cross_references":{"pubmed":["36613306"],"doi":["10.3390/foods12010090"]}}