biostudies-literatureMeissner ADirektör Albert Påhlssons Stiftelse för VälgörenhetLars Hierta Memorial FoundationSwedish Research CouncilAnna-Lisa Rosenberg FoundationRoyal Physiographic Society of Lund300https://www.ebi.ac.uk/biostudies/studies/S-EPMC9820346biostudies-literatureUnknown24(1)Excess dietary salt reduces resting cerebral blood flow (CBF) and vascular reactivity, which can limit the fueling of neuronal metabolism. It is hitherto unknown whether metabolic derangements induced by high-salt-diet (HSD) exposure during adulthood are reversed by reducing salt intake. In this study, male and female mice were fed an HSD from 9 to 16 months of age, followed by a normal-salt diet (ND) thereafter until 23 months of age. Controls were continuously fed either ND or HSD. CBF and metabolite profiles were determined longitudinally by arterial spin labeling magnetic resonance imaging and magnetic resonance spectroscopy, respectively. HSD reduced cortical and hippocampal CBF, which recovered after dietary salt normalization, and affected hippocampal but not cortical metabolite proInternational journal of molecular sciencesAlterations to Cerebral Perfusion, Metabolite Profiles, and Neuronal Morphology in the Hippocampus and Cortex of Male and Female Mice during Chronic Exposure to a High-Salt Diet.PMC98203462019-01130Larsson SMagnusson MMeissner AVanherle LSkoug CGottschalk MGarcia-Serrano AMDuarte JMNRafiee ZDon-Doncow NfalseAlterations to Cerebral Perfusion, Metabolite Profiles, and Neuronal Morphology in the Hippocampus and Cortex of Male and Female Mice during Chronic Exposure to a High-Salt Diet.Excess dietary salt reduces resting cerebral blood flow (CBF) and vascular reactivity, which can limit the fueling of neuronal metabolism. It is hitherto unknown whether metabolic derangements induced by high-salt-diet (HSD) exposure during adulthood are reversed by reducing salt intake. In this study, male and female mice were fed an HSD from 9 to 16 months of age, followed by a normal-salt diet (ND) thereafter until 23 months of age. Controls were continuously fed either ND or HSD. CBF and metabolite profiles were determined longitudinally by arterial spin labeling magnetic resonance imaging and magnetic resonance spectroscopy, respectively. HSD reduced cortical and hippocampal CBF, which recovered after dietary salt normalization, and affected hippocampal but not cortical metabolite pro2022-01-01T00:00:00Z2022 Dec2025-04-19T12:40:26.473Z2025-04-19T12:40:26.473ZS-EPMC98203463661374210.3390/ijms24010300