{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen S"],"funding":["earmarked fund for CARS","National Natural Science Foundation of China","National Key Research and Development Program of China","Key Research and Development Program of Hubei Province"],"pagination":["673"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9820476"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["The intestinal microbiota contributes to energy metabolism, but the molecular mechanisms involved remain less clear. Bacteria of the genus <i>Bacillus</i> regulate lipid metabolism in the host and are thus commonly used as beneficial probiotic supplements. In the present study, <i>Bacillus licheniformis</i> FA6 was selected to assess its role in modulating lipid metabolism of zebrafish (<i>Danio rerio</i>). Combining 16S rRNA high-throughput sequencing, micro-CT scan, metabolic parameters measurement, and gene expression analysis, we demonstrated that <i>B. licheniformis</i> FA6 changed the gut microbiota composition of zebrafish and increased both the Firmicutes/Bacteroidetes ratio and lipid accumulation. In terms of metabolites, <i>B. licheniformis</i> FA6 appeared to promote acetate pro"],"journal":["International journal of molecular sciences"],"pubmed_title":["<i>Bacillus licheniformis</i> FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation."],"pmcid":["PMC9820476"],"funding_grant_id":["2021BBA231","CARS-45","31872612","2020YFD0900303"],"pubmed_authors":["Zan Z","Zou H","Clements KD","Zhao W","Wu S","Ye W","Wang G","Chen S"],"additional_accession":[]},"is_claimable":false,"name":"<i>Bacillus licheniformis</i> FA6 Affects Zebrafish Lipid Metabolism through Promoting Acetyl-CoA Synthesis and Inhibiting β-Oxidation.","description":"The intestinal microbiota contributes to energy metabolism, but the molecular mechanisms involved remain less clear. Bacteria of the genus <i>Bacillus</i> regulate lipid metabolism in the host and are thus commonly used as beneficial probiotic supplements. In the present study, <i>Bacillus licheniformis</i> FA6 was selected to assess its role in modulating lipid metabolism of zebrafish (<i>Danio rerio</i>). Combining 16S rRNA high-throughput sequencing, micro-CT scan, metabolic parameters measurement, and gene expression analysis, we demonstrated that <i>B. licheniformis</i> FA6 changed the gut microbiota composition of zebrafish and increased both the Firmicutes/Bacteroidetes ratio and lipid accumulation. In terms of metabolites, <i>B. licheniformis</i> FA6 appeared to promote acetate pro","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-04-08T16:15:53.301Z","creation":"2025-04-21T16:18:52.392Z"},"accession":"S-EPMC9820476","cross_references":{"pubmed":["36614116"],"doi":["10.3390/ijms24010673"]}}