{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Khananshvili D"],"funding":["Israeli Science Foundation","Israel Science Foundation"],"pagination":["61"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9820601"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["The plasma-membrane homeostasis Na<sup>+</sup>/Ca<sup>2+</sup> exchangers (NCXs) mediate Ca<sup>2+</sup> extrusion/entry to dynamically shape Ca<sup>2+</sup> signaling/in biological systems ranging from bacteria to humans. The NCX gene orthologs, isoforms, and their splice variants are expressed in a tissue-specific manner and exhibit nearly 10<sup>4</sup>-fold differences in the transport rates and regulatory specificities to match the cell-specific requirements. Selective pharmacological targeting of NCX variants could benefit many clinical applications, although this intervention remains challenging, mainly because a full-size structure of eukaryotic NCX is unavailable. The crystal structure of the archaeal NCX_Mj, in conjunction with biophysical, computational, and functional analyses,"],"journal":["International journal of molecular sciences"],"pubmed_title":["Structure-Based Function and Regulation of NCX Variants: Updates and Challenges."],"pmcid":["PMC9820601"],"funding_grant_id":["1351/18","852/14"],"pubmed_authors":["Khananshvili D"],"additional_accession":[]},"is_claimable":false,"name":"Structure-Based Function and Regulation of NCX Variants: Updates and Challenges.","description":"The plasma-membrane homeostasis Na<sup>+</sup>/Ca<sup>2+</sup> exchangers (NCXs) mediate Ca<sup>2+</sup> extrusion/entry to dynamically shape Ca<sup>2+</sup> signaling/in biological systems ranging from bacteria to humans. The NCX gene orthologs, isoforms, and their splice variants are expressed in a tissue-specific manner and exhibit nearly 10<sup>4</sup>-fold differences in the transport rates and regulatory specificities to match the cell-specific requirements. Selective pharmacological targeting of NCX variants could benefit many clinical applications, although this intervention remains challenging, mainly because a full-size structure of eukaryotic NCX is unavailable. The crystal structure of the archaeal NCX_Mj, in conjunction with biophysical, computational, and functional analyses,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-06-01T02:35:27.476Z","creation":"2024-11-15T07:49:40.776Z"},"accession":"S-EPMC9820601","cross_references":{"pubmed":["36613523"],"doi":["10.3390/ijms24010061"]}}