{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Falquet M"],"funding":["The Research Council of Norway","Northern Norway Regional Health Authority"],"pagination":["895"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9820997"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["Merkel cell polyomavirus (MCPyV) is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. MCPyV large T-antigen (LTag) and small T-antigen (sTag) are the main oncoproteins involved in MCPyV-induced MCC. A hallmark of MCPyV-positive MCC cells is the expression of a C-terminal truncated LTag. Protein kinase A (PKA) plays a fundamental role in a variety of biological processes, including transcription by phosphorylating and thereby regulating the activity of transcription factors. As MCPyV LTag has been shown to be phosphorylated and acts as a transcription factor for the viral early and late promoter, we investigated whether LTag can be phosphorylayted by PKA, and whether this affects the transcript activity of LTag. Using a phosphorylation prediction algorithm, serine 1"],"journal":["International journal of molecular sciences"],"pubmed_title":["Regulation of Transcriptional Activity of Merkel Cell Polyomavirus Large T-Antigen by PKA-Mediated Phosphorylation."],"pmcid":["PMC9820997"],"funding_grant_id":["295910","HNF1441-18 and HNF1596-21"],"pubmed_authors":["Passerini S","Ludvigsen M","Moens U","Prezioso C","Sveinbjornsson B","Bruun JA","Pietropaolo V","Falquet M"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of Transcriptional Activity of Merkel Cell Polyomavirus Large T-Antigen by PKA-Mediated Phosphorylation.","description":"Merkel cell polyomavirus (MCPyV) is the major cause of Merkel cell carcinoma (MCC), an aggressive skin cancer. MCPyV large T-antigen (LTag) and small T-antigen (sTag) are the main oncoproteins involved in MCPyV-induced MCC. A hallmark of MCPyV-positive MCC cells is the expression of a C-terminal truncated LTag. Protein kinase A (PKA) plays a fundamental role in a variety of biological processes, including transcription by phosphorylating and thereby regulating the activity of transcription factors. As MCPyV LTag has been shown to be phosphorylated and acts as a transcription factor for the viral early and late promoter, we investigated whether LTag can be phosphorylayted by PKA, and whether this affects the transcript activity of LTag. Using a phosphorylation prediction algorithm, serine 1","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-21T16:21:23.832Z","creation":"2025-04-21T16:21:23.832Z"},"accession":"S-EPMC9820997","cross_references":{"pubmed":["36614338"],"doi":["10.3390/ijms24010895"]}}