{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amagai R"],"funding":["GlaxoSmithKline Japan","Japan Society for the Promotion of Science"],"pagination":["875"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9821026"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["An active form of cathelicidin antimicrobial peptide, LL-37, has immunomodulatory and stimulatory effects, though the specific pathways are not clear. The purpose of this study was to identify the cellular pathways by which LL-37 amplifies the inflammation induced by damage-associated molecular patterns (DAMPs). We performed DNA microarray, reverse transcription polymerase chain reaction, immunoblotting, and proximity ligation assays using cultured keratinocytes treated with LL-37 and/or the DAMP poly(I:C), a synthetic double-stranded RNA. In contrast to the combination of LL-37 and poly(I:C), LL-37 alone induced genes related to biological metabolic processes such as VEGFA and PTGS2 (COX-2). Inhibition of FPR2, a known receptor for cathelicidin, partially suppressed the induction of VEGFA"],"journal":["International journal of molecular sciences"],"pubmed_title":["The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors."],"pmcid":["PMC9821026"],"funding_grant_id":["19K21251","20K17304","Research Grant 2019","18H06136"],"pubmed_authors":["Takahashi T","Fujimura T","Asano Y","Yamasaki K","Aiba S","Amagai R","Terui H"],"additional_accession":[]},"is_claimable":false,"name":"The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors.","description":"An active form of cathelicidin antimicrobial peptide, LL-37, has immunomodulatory and stimulatory effects, though the specific pathways are not clear. The purpose of this study was to identify the cellular pathways by which LL-37 amplifies the inflammation induced by damage-associated molecular patterns (DAMPs). We performed DNA microarray, reverse transcription polymerase chain reaction, immunoblotting, and proximity ligation assays using cultured keratinocytes treated with LL-37 and/or the DAMP poly(I:C), a synthetic double-stranded RNA. In contrast to the combination of LL-37 and poly(I:C), LL-37 alone induced genes related to biological metabolic processes such as VEGFA and PTGS2 (COX-2). Inhibition of FPR2, a known receptor for cathelicidin, partially suppressed the induction of VEGFA","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-21T16:18:08.1Z","creation":"2025-04-21T16:18:08.1Z"},"accession":"S-EPMC9821026","cross_references":{"pubmed":["36614313"],"doi":["10.3390/ijms24010875"]}}