biostudies-literatureWu HThe Guangdong Basic and Applied Basic Research FoundationThe Natural Science Foundation for Distinguished Young Scholars of Guangdong ProvinceThe Climbing Program of Introduced Talents and High-level Hospital Construction Project of Guangdong Provincial People’s HospitalThe Program for High-level Foreign Expert Introduction of ChinaThe Climbing Program of Introduced Talents and High-level Hospital Construction Project of Guangdong Provincial People's HospitalThe National Natural Science Foundation of China68https://www.ebi.ac.uk/biostudies/studies/S-EPMC9822216biostudies-literatureUnknown28(1)Ulcerative colitis is a chronic inflammatory bowel disorder that is hard to cure once diagnosed. Bisdemethoxycurcumin has shown positive effects on inflammatory diseases. However, the underlying bioactive interaction between bisdemethoxycurcumin and ulcerative colitis is unclear. The objective of this study was to determine the core target and potential mechanism of action of bisdemethoxycurcumin as a therapy for ulcerative colitis. The public databases were used to identify potential targets for bisdemethoxycurcumin and ulcerative colitis. To investigate the potential mechanisms, the protein-protein interaction network, gene ontology analysis, and Kyoto encyclopedia of genes and genomes analysis have been carried out. Subsequently, experimental verification was conducted to confirm the fiMolecules (Basel, Switzerland)Investigating the Mechanisms of Bisdemethoxycurcumin in Ulcerative Colitis: Network Pharmacology and Experimental Verification.PMC9822216DFJH201803, KJ012019099, KJ012021143, KY0120211832021B1515020003KY0120211838130027982171698KJ01202114381300279,8174106782171698, 8217056182170561DFJH201803817410672022A1515012081G2022030047LKJ012019099Zeng RSha WTu SZhuo ZJiang RYang QChen HLian QWu HfalseInvestigating the Mechanisms of Bisdemethoxycurcumin in Ulcerative Colitis: Network Pharmacology and Experimental Verification.Ulcerative colitis is a chronic inflammatory bowel disorder that is hard to cure once diagnosed. Bisdemethoxycurcumin has shown positive effects on inflammatory diseases. However, the underlying bioactive interaction between bisdemethoxycurcumin and ulcerative colitis is unclear. The objective of this study was to determine the core target and potential mechanism of action of bisdemethoxycurcumin as a therapy for ulcerative colitis. The public databases were used to identify potential targets for bisdemethoxycurcumin and ulcerative colitis. To investigate the potential mechanisms, the protein-protein interaction network, gene ontology analysis, and Kyoto encyclopedia of genes and genomes analysis have been carried out. Subsequently, experimental verification was conducted to confirm the fi2022-01-01T00:00:00Z2022 Dec2026-04-08T11:16:06.405Z2025-02-18T22:34:20.638ZS-EPMC98222163661526410.3390/molecules28010068