biostudies-literatureAnchesi IMinistero della Salute193https://www.ebi.ac.uk/biostudies/studies/S-EPMC9823669biostudies-literatureUnknown12(1)Cannabigerol (CBG) is a non-psychoactive phytocannabinoid present in the <i>Cannabis sativa</i> L. plant. In our study, CBG at the concentration of 10 µM was used to treat NSC-34 motor neuron-like cells. The aim of the study was to evaluate the effects of CBG on NSC-34 cells, using next-generation sequencing (NGS) technology. Analysis showed the activation of the WNT/planar cell polarity (PCP) pathway and Ephrin-Eph signaling. The results revealed that CBG increases the expression of genes associated with the onset process of cytoskeletal remodeling and axon guidance.Plants (Basel, Switzerland)Cannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study.PMC9823669Current Research Funds 2022Anchesi ISalamone SGugliandolo APollastro FMazzon EChiricosta LBetto FfalseCannabigerol Activates Cytoskeletal Remodeling via Wnt/PCP in NSC-34: An In Vitro Transcriptional Study.Cannabigerol (CBG) is a non-psychoactive phytocannabinoid present in the <i>Cannabis sativa</i> L. plant. In our study, CBG at the concentration of 10 µM was used to treat NSC-34 motor neuron-like cells. The aim of the study was to evaluate the effects of CBG on NSC-34 cells, using next-generation sequencing (NGS) technology. Analysis showed the activation of the WNT/planar cell polarity (PCP) pathway and Ephrin-Eph signaling. The results revealed that CBG increases the expression of genes associated with the onset process of cytoskeletal remodeling and axon guidance.2023-01-01T00:00:00Z2023 Jan2025-04-21T16:19:33.023Z2024-11-08T22:05:34.056ZS-EPMC98236693661632210.3390/plants12010193