{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song W"],"funding":["Career Development Program for Young Teachers of Shenyang Pharmaceutical University","Natural Science Foundation of Liaoning Province","Scientific Research Funding Project of Liaoning Provincial Department of Education"],"pagination":["390"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9823930"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(1)"],"pubmed_abstract":["Diabetes mellitus (DM) is a major risk factor for stroke and exacerbates white-matter damage in focal cerebral ischemia. Our previous study showed that the sigma-1 receptor agonist PRE084 ameliorates bilateral common-carotid-artery occlusion-induced brain damage in mice. However, whether this protective effect can extend to white matter remains unclear. In this study, C57BL/6 mice were treated with high-fat diets (HFDs) combined with streptozotocin (STZ) injection to mimic type 2 diabetes mellitus (T2DM). Focal cerebral ischemia in T2DM mice was established via injection of the vasoconstrictor peptide endothelin-1 (ET-1) into the hippocampus. Three different treatment plans were used in this study. In one plan, 1 mg/kg of PRE084 (intraperitoneally) was administered for 7 d before ET-1 inje"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Sigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus."],"pmcid":["PMC9823930"],"funding_grant_id":["LJKZ0914","2021-MS-212","2020LJC14","ZQN2021004"],"pubmed_authors":["Zhou L","Yao Y","Ji X","Zou L","Wei T","Zhang H","Chi T","Liu P","Hao X","Song W","Song Z"],"additional_accession":[]},"is_claimable":false,"name":"Sigma-1 Receptor Activation Improves Oligodendrogenesis and Promotes White-Matter Integrity after Stroke in Mice with Diabetic Mellitus.","description":"Diabetes mellitus (DM) is a major risk factor for stroke and exacerbates white-matter damage in focal cerebral ischemia. Our previous study showed that the sigma-1 receptor agonist PRE084 ameliorates bilateral common-carotid-artery occlusion-induced brain damage in mice. However, whether this protective effect can extend to white matter remains unclear. In this study, C57BL/6 mice were treated with high-fat diets (HFDs) combined with streptozotocin (STZ) injection to mimic type 2 diabetes mellitus (T2DM). Focal cerebral ischemia in T2DM mice was established via injection of the vasoconstrictor peptide endothelin-1 (ET-1) into the hippocampus. Three different treatment plans were used in this study. In one plan, 1 mg/kg of PRE084 (intraperitoneally) was administered for 7 d before ET-1 inje","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-21T16:21:58.72Z","creation":"2025-04-21T16:21:58.72Z"},"accession":"S-EPMC9823930","cross_references":{"pubmed":["36615583"],"doi":["10.3390/molecules28010390"]}}