{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wu Q"],"funding":["Open Project Program of State Key Laboratory of Food Science and Technology, Jiangnan Uni-versity","National Natural Science Foundation of China","Open Project Program of State Key Laboratory of Food Science and Technology, Jiangnan University"],"pagination":["445"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9824641"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(1)"],"pubmed_abstract":["Cannabidiol (CBD) from Cannabis sativa is used in cosmetics in North America due to its antibacterial and antioxidant properties, but has been prohibited in many countries except recently; so, finding a non-intoxicating CBD alternative and elucidating the structure−function relationship of CBD analogues is becoming increasingly relevant. Herein, a set of CBD analogues including 8,9-dihydrocannabidiol (H2CBD) was synthesized, and their antibacterial, bactericidal, and antioxidant activity, as well as their structure−function relationship, were studied. The results present a catalytic selectivity near 100% towards H2CBD with a production yield of 85%. Each CBD analogue presented different antibacterial and antioxidant activity. It is revealed that the phenolic hydroxyl moiety is an essential"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["8,9-Dihydrocannabidiol, an Alternative of Cannabidiol, Its Preparation, Antibacterial and Antioxidant Ability."],"pmcid":["PMC9824641"],"funding_grant_id":["31772017","SKLF-KF-2022"],"pubmed_authors":["Xia Y","Guo M","Zou L","Wang Q","Wu Q"],"additional_accession":[]},"is_claimable":false,"name":"8,9-Dihydrocannabidiol, an Alternative of Cannabidiol, Its Preparation, Antibacterial and Antioxidant Ability.","description":"Cannabidiol (CBD) from Cannabis sativa is used in cosmetics in North America due to its antibacterial and antioxidant properties, but has been prohibited in many countries except recently; so, finding a non-intoxicating CBD alternative and elucidating the structure−function relationship of CBD analogues is becoming increasingly relevant. Herein, a set of CBD analogues including 8,9-dihydrocannabidiol (H2CBD) was synthesized, and their antibacterial, bactericidal, and antioxidant activity, as well as their structure−function relationship, were studied. The results present a catalytic selectivity near 100% towards H2CBD with a production yield of 85%. Each CBD analogue presented different antibacterial and antioxidant activity. It is revealed that the phenolic hydroxyl moiety is an essential","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-08-12T03:04:49.988Z","creation":"2025-04-04T07:21:31.813Z"},"accession":"S-EPMC9824641","cross_references":{"pubmed":["36615636"],"doi":["10.3390/molecules28010445"]}}