biostudies-literatureUnknown23(1)Ke C<h4>Background</h4>Hepatocellular carcinoma (HCC) is a common abdominal cancer with dissatisfactory therapeutic effects. The discovery of cuproptosis lights on new approach for cancer treatment and assessment. So far, there is extremely limited research investigating the roles of cuproptosis-related (CR) genes in cancers.<h4>Methods</h4>A novel CR risk signature was constructed using the Lasso regression analysis. Its prognostic value was assessed via a series of survival analyses and validated in three GEO cohorts. The effects of CR risk signature on tumor immune microenvironment (TIM) were explored through CIBERSORT, ESTIMATE, and ssGSEA algorithms. Using GESA, we investigated its impacts on various metabolism process. The somatic mutation features of CR signature genes were also exploreBMC cancer25https://www.ebi.ac.uk/biostudies/studies/S-EPMC9824945biostudies-literatureCuproptosis regulatory genes greatly contribute to clinical assessments of hepatocellular carcinoma.PMC9824945Li YDai SYang LXu FChen YKe CYuan JFan SfalseCuproptosis regulatory genes greatly contribute to clinical assessments of hepatocellular carcinoma.<h4>Background</h4>Hepatocellular carcinoma (HCC) is a common abdominal cancer with dissatisfactory therapeutic effects. The discovery of cuproptosis lights on new approach for cancer treatment and assessment. So far, there is extremely limited research investigating the roles of cuproptosis-related (CR) genes in cancers.<h4>Methods</h4>A novel CR risk signature was constructed using the Lasso regression analysis. Its prognostic value was assessed via a series of survival analyses and validated in three GEO cohorts. The effects of CR risk signature on tumor immune microenvironment (TIM) were explored through CIBERSORT, ESTIMATE, and ssGSEA algorithms. Using GESA, we investigated its impacts on various metabolism process. The somatic mutation features of CR signature genes were also explore2023-01-01T00:00:00Z2023 Jan2025-04-26T06:00:24.462Z2025-04-06T11:44:13.767ZS-EPMC98249453661115510.1186/s12885-022-10461-2