biostudies-literatureYu JLBiotechnological and Biological Research CouncilCancer Research UK111 ProjectNational Natural Science Foundation of ChinaBiotechnology and Biological Sciences Research CouncilSichuan Science and Technology ProgramD593-D602https://www.ebi.ac.uk/biostudies/studies/S-EPMC9825548biostudies-literatureUnknown51(D1)Metalloenzymes are attractive research targets in fields of chemistry, biology, and medicine. Given that metalloenzymes can manifest conservation of metal-coordination and ligand binding modes, the excavation and expansion of metalloenzyme-specific knowledge is of interest in bridging metalloenzyme-related fields. Building on our previous metalloenzyme-ligand association database, MeLAD, we have expanded the scope of metalloenzyme-specific knowledge and services, by forming a versatile platform, termed the Metalloenzyme Data Bank and Analysis (MeDBA). The MeDBA provides: (i) manual curation of metalloenzymes into different categories, that this M-I, M-II and M-III; (ii) comprehensive information on metalloenzyme activities, expression profiles, family and disease links; (iii) structural inNucleic acids researchMeDBA: the Metalloenzyme Data Bank and Analysis platform.PMC98255482022YFH0027BB/V003291/182073698BB/V001892/1B180358212206581874291Li GBDai QQZhou CWu SYu JLSchofield CJfalseMeDBA: the Metalloenzyme Data Bank and Analysis platform.Metalloenzymes are attractive research targets in fields of chemistry, biology, and medicine. Given that metalloenzymes can manifest conservation of metal-coordination and ligand binding modes, the excavation and expansion of metalloenzyme-specific knowledge is of interest in bridging metalloenzyme-related fields. Building on our previous metalloenzyme-ligand association database, MeLAD, we have expanded the scope of metalloenzyme-specific knowledge and services, by forming a versatile platform, termed the Metalloenzyme Data Bank and Analysis (MeDBA). The MeDBA provides: (i) manual curation of metalloenzymes into different categories, that this M-I, M-II and M-III; (ii) comprehensive information on metalloenzyme activities, expression profiles, family and disease links; (iii) structural in2023-01-01T00:00:00Z2023 Jan2026-05-27T11:04:30.904Z2026-04-08T01:37:47.343ZS-EPMC98255483624397110.1093/nar/gkac860