biostudies-literatureZhang YNational Natural Science Foundation of ChinaWu Liande Youth Science Research Fund of Harbin Medical UniversityResearch Foundation of the First Affiliated Hospital of University of South China for Advanced TalentsD88-D100https://www.ebi.ac.uk/biostudies/studies/S-EPMC9825595biostudies-literatureUnknown51(D1)Chromatin regulators (CRs) regulate epigenetic patterns on a partial or global scale, playing a critical role in affecting multi-target gene expression. As chromatin immunoprecipitation sequencing (ChIP-seq) data associated with CRs are rapidly accumulating, a comprehensive resource of CRs needs to be built urgently for collecting, integrating, and processing these data, which can provide abundant annotated information on CR upstream and downstream regulatory analyses as well as CR-related analysis functions. This study established an integrative CR resource, named CRdb (http://cr.liclab.net/crdb/), with the aim of curating a large number of available resources for CRs and providing extensive annotations and analyses of CRs to help biological researchers clarify the regulation mechanism anNucleic acids researchCRdb: a comprehensive resource for deciphering chromatin regulators in human.PMC9825595JFWLD20200120210002–100581872372620011458217303482273108Xu LZhou LLi CLi ESong CFeng CZhao XZhu JWang QAi BZhang YFang QWang YSun HXu XfalseCRdb: a comprehensive resource for deciphering chromatin regulators in human.Chromatin regulators (CRs) regulate epigenetic patterns on a partial or global scale, playing a critical role in affecting multi-target gene expression. As chromatin immunoprecipitation sequencing (ChIP-seq) data associated with CRs are rapidly accumulating, a comprehensive resource of CRs needs to be built urgently for collecting, integrating, and processing these data, which can provide abundant annotated information on CR upstream and downstream regulatory analyses as well as CR-related analysis functions. This study established an integrative CR resource, named CRdb (http://cr.liclab.net/crdb/), with the aim of curating a large number of available resources for CRs and providing extensive annotations and analyses of CRs to help biological researchers clarify the regulation mechanism an2023-01-01T00:00:00Z2023 Jan2025-04-26T06:00:30.751Z2025-04-06T11:45:55.97ZS-EPMC98255953631825610.1093/nar/gkac960