{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lo Surdo P"],"funding":["Italian Association for Cancer Research"],"pagination":["D631-D637"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9825604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(D1)"],"pubmed_abstract":["The SIGnaling Network Open Resource (SIGNOR 3.0, https://signor.uniroma2.it) is a public repository that captures causal information and represents it according to an 'activity-flow' model. SIGNOR provides freely-accessible static maps of causal interactions that can be tailored, pruned and refined to build dynamic and predictive models. Each signaling relationship is annotated with an effect (up/down-regulation) and with the mechanism (e.g. binding, phosphorylation, transcriptional activation, etc.) causing the regulation of the target entity. Since its latest release, SIGNOR has undergone a significant upgrade including: (i) a new website that offers an improved user experience and novel advanced search and graph tools; (ii) a significant content growth adding up to a total of approx. 33"],"journal":["Nucleic acids research"],"pubmed_title":["SIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update."],"pmcid":["PMC9825604"],"funding_grant_id":["20322"],"pubmed_authors":["Licata L","Castagnoli L","Cesareni G","Perfetto L","Contino S","Lo Surdo P","Iannuccelli M"],"additional_accession":[]},"is_claimable":false,"name":"SIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update.","description":"The SIGnaling Network Open Resource (SIGNOR 3.0, https://signor.uniroma2.it) is a public repository that captures causal information and represents it according to an 'activity-flow' model. SIGNOR provides freely-accessible static maps of causal interactions that can be tailored, pruned and refined to build dynamic and predictive models. Each signaling relationship is annotated with an effect (up/down-regulation) and with the mechanism (e.g. binding, phosphorylation, transcriptional activation, etc.) causing the regulation of the target entity. Since its latest release, SIGNOR has undergone a significant upgrade including: (i) a new website that offers an improved user experience and novel advanced search and graph tools; (ii) a significant content growth adding up to a total of approx. 33","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-21T17:55:48.062Z","creation":"2025-04-05T17:03:41.959Z"},"accession":"S-EPMC9825604","cross_references":{"pubmed":["36243968"],"doi":["10.1093/nar/gkac883"]}}