biostudies-literatureLo Surdo PItalian Association for Cancer ResearchD631-D637https://www.ebi.ac.uk/biostudies/studies/S-EPMC9825604biostudies-literatureUnknown51(D1)The SIGnaling Network Open Resource (SIGNOR 3.0, https://signor.uniroma2.it) is a public repository that captures causal information and represents it according to an 'activity-flow' model. SIGNOR provides freely-accessible static maps of causal interactions that can be tailored, pruned and refined to build dynamic and predictive models. Each signaling relationship is annotated with an effect (up/down-regulation) and with the mechanism (e.g. binding, phosphorylation, transcriptional activation, etc.) causing the regulation of the target entity. Since its latest release, SIGNOR has undergone a significant upgrade including: (i) a new website that offers an improved user experience and novel advanced search and graph tools; (ii) a significant content growth adding up to a total of approx. 33Nucleic acids researchSIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update.PMC982560420322Licata LCastagnoli LCesareni GPerfetto LContino SLo Surdo PIannuccelli MfalseSIGNOR 3.0, the SIGnaling network open resource 3.0: 2022 update.The SIGnaling Network Open Resource (SIGNOR 3.0, https://signor.uniroma2.it) is a public repository that captures causal information and represents it according to an 'activity-flow' model. SIGNOR provides freely-accessible static maps of causal interactions that can be tailored, pruned and refined to build dynamic and predictive models. Each signaling relationship is annotated with an effect (up/down-regulation) and with the mechanism (e.g. binding, phosphorylation, transcriptional activation, etc.) causing the regulation of the target entity. Since its latest release, SIGNOR has undergone a significant upgrade including: (i) a new website that offers an improved user experience and novel advanced search and graph tools; (ii) a significant content growth adding up to a total of approx. 332023-01-01T00:00:00Z2023 Jan2025-04-21T17:55:48.062Z2025-04-05T17:03:41.959ZS-EPMC98256043624396810.1093/nar/gkac883