{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gaffin JM"],"funding":["NCATS NIH HHS","NIAID NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS"],"pagination":["138-146.e9"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9825637"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["151(1)"],"pubmed_abstract":["<h4>Background</h4>Children with asthma are at risk for low lung function extending into adulthood, but understanding of clinical predictors is incomplete.<h4>Objective</h4>We sought to determine phenotypic factors associated with FEV<sub>1</sub> throughout childhood in the Severe Asthma Research Program 3 pediatric cohort.<h4>Methods</h4>Lung function was measured at baseline and annually. Multivariate linear mixed-effects models were constructed to assess the effect of baseline and time-varying predictors of prebronchodilator FEV<sub>1</sub> at each assessment for up to 6 years. All models were adjusted for age, predicted FEV<sub>1</sub> by Global Lung Function Initiative reference equations, race, sex, and height. Secondary outcomes included postbronchodilator FEV<sub>1</sub> and prebro"],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3."],"pmcid":["PMC9825637"],"funding_grant_id":["R01 AI073964","UL1 TR002373","UL1 TR000454","UL1 TR001102","UL1 TR001420","T32 AI007635","UL1 TR000427","U10 HL109257","U01 HL146002","U10 HL109168","U10 HL109146","R01 ES030100","U10 HL109164","U10 HL109086","U10 HL109152","U10 HL109250","U10 HL109172"],"pubmed_authors":["Denlinger LC","Teague WG","Bacharier LB","Wenzel SE","Sorkness RL","Ramratnam S","National Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 Investigators","DeBoer MD","Ly NP","Gaffin JM","Petty CR","Israel E","Ross K","Mauger DT","Phipatanakul W","Phillips BR","Gaston B","Fitzpatrick A"],"additional_accession":[]},"is_claimable":false,"name":"Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3.","description":"<h4>Background</h4>Children with asthma are at risk for low lung function extending into adulthood, but understanding of clinical predictors is incomplete.<h4>Objective</h4>We sought to determine phenotypic factors associated with FEV<sub>1</sub> throughout childhood in the Severe Asthma Research Program 3 pediatric cohort.<h4>Methods</h4>Lung function was measured at baseline and annually. Multivariate linear mixed-effects models were constructed to assess the effect of baseline and time-varying predictors of prebronchodilator FEV<sub>1</sub> at each assessment for up to 6 years. All models were adjusted for age, predicted FEV<sub>1</sub> by Global Lung Function Initiative reference equations, race, sex, and height. Secondary outcomes included postbronchodilator FEV<sub>1</sub> and prebro","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-05-28T01:55:40.286Z","creation":"2025-04-04T19:00:53.153Z"},"accession":"S-EPMC9825637","cross_references":{"pubmed":["36041656"],"doi":["10.1016/j.jaci.2022.08.014"]}}