biostudies-literatureGaffin JMNCATS NIH HHSNIAID NIH HHSNIEHS NIH HHSNHLBI NIH HHS138-146.e9https://www.ebi.ac.uk/biostudies/studies/S-EPMC9825637biostudies-literatureUnknown151(1)<h4>Background</h4>Children with asthma are at risk for low lung function extending into adulthood, but understanding of clinical predictors is incomplete.<h4>Objective</h4>We sought to determine phenotypic factors associated with FEV₁ throughout childhood in the Severe Asthma Research Program 3 pediatric cohort.<h4>Methods</h4>Lung function was measured at baseline and annually. Multivariate linear mixed-effects models were constructed to assess the effect of baseline and time-varying predictors of prebronchodilator FEV₁ at each assessment for up to 6 years. All models were adjusted for age, predicted FEV₁ by Global Lung Function Initiative reference equations, race, sex, and height. Secondary outcomes included postbronchodilator FEV₁ and prebroThe Journal of allergy and clinical immunologyDeterminants of lung function across childhood in the Severe Asthma Research Program (SARP) 3.PMC9825637R01 AI073964UL1 TR002373UL1 TR000454UL1 TR001102UL1 TR001420T32 AI007635UL1 TR000427U10 HL109257U01 HL146002U10 HL109168U10 HL109146R01 ES030100U10 HL109164U10 HL109086U10 HL109152U10 HL109250U10 HL109172Denlinger LCTeague WGBacharier LBWenzel SESorkness RLRamratnam SNational Heart, Lung, and Blood Institute’s Severe Asthma Research Program-3 InvestigatorsDeBoer MDLy NPGaffin JMPetty CRIsrael ERoss KMauger DTPhipatanakul WPhillips BRGaston BFitzpatrick AfalseDeterminants of lung function across childhood in the Severe Asthma Research Program (SARP) 3.<h4>Background</h4>Children with asthma are at risk for low lung function extending into adulthood, but understanding of clinical predictors is incomplete.<h4>Objective</h4>We sought to determine phenotypic factors associated with FEV₁ throughout childhood in the Severe Asthma Research Program 3 pediatric cohort.<h4>Methods</h4>Lung function was measured at baseline and annually. Multivariate linear mixed-effects models were constructed to assess the effect of baseline and time-varying predictors of prebronchodilator FEV₁ at each assessment for up to 6 years. All models were adjusted for age, predicted FEV₁ by Global Lung Function Initiative reference equations, race, sex, and height. Secondary outcomes included postbronchodilator FEV₁ and prebro2023-01-01T00:00:00Z2023 Jan2026-05-28T01:55:40.286Z2025-04-04T19:00:53.153ZS-EPMC98256373604165610.1016/j.jaci.2022.08.014