biostudies-literatureKondev VNIMHNIMH NIH HHSNational Institutes of Health739-749https://www.ebi.ac.uk/biostudies/studies/S-EPMC9827751biostudies-literatureUnknown92(9)<h4>Background</h4>Stress-related disorders are among the most prevalent psychiatric disorders, characterized by excess fear and enhanced avoidance of trauma triggers. Elucidating the mechanisms regulating temporally distinct aspects of innate and conditioned fear responses could facilitate novel therapeutic development for stress-related disorders. One potential target that has recently emerged is the endocannabinoid system, which has been reported to mediate the physiological response to stress and represents an important substrate underlying individual differences in stress susceptibility.<h4>Methods</h4>Here, we exposed male and female CD-1 mice to an innate predator stressor, 2MT (2-methyl-2-thiazoline), to investigate the ability of endocannabinoid signaling to modulate temporally diBiological psychiatryThe Endocannabinoid 2-Arachidonoylglycerol Bidirectionally Modulates Acute and Protracted Effects of Predator Odor Exposure.PMC9827751F31 MH126460MH119817R01 MH119817R01 MH107435MH107435Kondev VNajeed MWinters NDPatel SKingsley PJMarnett LMorgan AfalseThe Endocannabinoid 2-Arachidonoylglycerol Bidirectionally Modulates Acute and Protracted Effects of Predator Odor Exposure.<h4>Background</h4>Stress-related disorders are among the most prevalent psychiatric disorders, characterized by excess fear and enhanced avoidance of trauma triggers. Elucidating the mechanisms regulating temporally distinct aspects of innate and conditioned fear responses could facilitate novel therapeutic development for stress-related disorders. One potential target that has recently emerged is the endocannabinoid system, which has been reported to mediate the physiological response to stress and represents an important substrate underlying individual differences in stress susceptibility.<h4>Methods</h4>Here, we exposed male and female CD-1 mice to an innate predator stressor, 2MT (2-methyl-2-thiazoline), to investigate the ability of endocannabinoid signaling to modulate temporally di2022-01-01T00:00:00Z2022 Nov2025-04-21T14:00:41.311Z2025-04-21T14:00:41.311ZS-EPMC98277513596179110.1016/j.biopsych.2022.05.012