{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Q"],"funding":["Vetenskapsrådet","Knut och Alice Wallenbergs Stiftelse"],"pagination":["e202210509"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9828052"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(46)"],"pubmed_abstract":["We report herein a new method for the synthesis of densely functionalized chiral allyl SCF<sub>3</sub> , SCF<sub>2</sub> R, SCN and SAr species with a separate CF<sub>3</sub> functionality. The synthetic approach is based on selenium-catalyzed sulfenofunctionalization of chiral α-CF<sub>3</sub> allylboronic acids. The reactions proceeded with remarkably high stereo-, diastereo- and site-selectivity, based on the formation of a stable thiiranium ion followed by rapid deborylative ring opening."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Sulfenofunctionalization of Chiral α-Trifluoromethyl Allylboronic Acids: Asymmetric Synthesis of SCF<sub>3</sub> , SCF<sub>2</sub> R, SCN and SAr Compounds."],"pmcid":["PMC9828052"],"funding_grant_id":["2021-04282","2018.0066"],"pubmed_authors":["Wang Q","Nilsson T","Eriksson L","Szabo KJ"],"additional_accession":[]},"is_claimable":false,"name":"Sulfenofunctionalization of Chiral α-Trifluoromethyl Allylboronic Acids: Asymmetric Synthesis of SCF<sub>3</sub> , SCF<sub>2</sub> R, SCN and SAr Compounds.","description":"We report herein a new method for the synthesis of densely functionalized chiral allyl SCF<sub>3</sub> , SCF<sub>2</sub> R, SCN and SAr species with a separate CF<sub>3</sub> functionality. The synthetic approach is based on selenium-catalyzed sulfenofunctionalization of chiral α-CF<sub>3</sub> allylboronic acids. The reactions proceeded with remarkably high stereo-, diastereo- and site-selectivity, based on the formation of a stable thiiranium ion followed by rapid deborylative ring opening.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-03-18T13:51:17.858Z","creation":"2025-04-21T14:02:10.173Z"},"accession":"S-EPMC9828052","cross_references":{"pubmed":["36152310"],"doi":["10.1002/anie.202210509"]}}