{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Walker DM"],"funding":["NIDA NIH HHS","NIA NIH HHS","NIMH NIH HHS"],"pagination":["895-906"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9828478"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["92(11)"],"pubmed_abstract":["Background
Social experiences influence susceptibility to substance use disorder. The adolescent period is associated with the development of social reward and is exceptionally sensitive to disruptions to reward-associated behaviors by social experiences. Social isolation (SI) during adolescence alters anxiety- and reward-related behaviors in adult males, but little is known about females. The medial amygdala (meA) is a likely candidate for the modulation of social influence on drug reward because it regulates social reward, develops during adolescence, and is sensitive to social stress. However, little is known regarding how the meA responds to drugs of abuse.Methods
We used adolescent SI coupled with RNA sequencing to better understand the molecular mechanisms underlying "],"journal":["Biological psychiatry"],"pubmed_title":["Crystallin Mu in Medial Amygdala Mediates the Effect of Social Experience on Cocaine Seeking in Males but Not in Females."],"pmcid":["PMC9828478"],"funding_grant_id":["R37 DA007359","RF1 AG054014","R00 DA042100","K99 DA042100","R01 MH051399","U01 AG046170","R01 DA007359","P01 DA047233"],"pubmed_authors":["Cates HM","Shen L","Hodes GE","Parise EM","Godino A","Ramakrishnan A","Cunningham AM","Zhou X","Nestler EJ","Torres-Berrio A","Lipschultz AP","Browne CJ","Pena CJ","Bagot RC","Van der Zee Y","Walker DM","Lardner CK","Zhang B","Issler O","Kennedy PJ"],"additional_accession":[]},"is_claimable":false,"name":"Crystallin Mu in Medial Amygdala Mediates the Effect of Social Experience on Cocaine Seeking in Males but Not in Females.","description":"Background
Social experiences influence susceptibility to substance use disorder. The adolescent period is associated with the development of social reward and is exceptionally sensitive to disruptions to reward-associated behaviors by social experiences. Social isolation (SI) during adolescence alters anxiety- and reward-related behaviors in adult males, but little is known about females. The medial amygdala (meA) is a likely candidate for the modulation of social influence on drug reward because it regulates social reward, develops during adolescence, and is sensitive to social stress. However, little is known regarding how the meA responds to drugs of abuse.Methods
We used adolescent SI coupled with RNA sequencing to better understand the molecular mechanisms underlying ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-29T04:43:45.884Z","creation":"2024-11-09T00:25:43.816Z"},"accession":"S-EPMC9828478","cross_references":{"pubmed":["36182529"],"doi":["10.1016/j.biopsych.2022.06.026"]}}