biostudies-literaturevan Osch TLJPPOC grant from Stichting Sanquin bloedvoorziening3011-3025https://www.ebi.ac.uk/biostudies/studies/S-EPMC9828502biostudies-literatureUnknown20(12)<h4>Background</h4>The formation of alloantibodies directed against class I human leukocyte antigens (HLA) continues to be a clinically challenging complication after platelet transfusions, which can lead to platelet refractoriness (PR) and occurs in approximately 5%-15% of patients with chronic platelet support. Interestingly, anti-HLA IgG levels in alloimmunized patients do not seem to predict PR, suggesting functional or qualitative differences among anti-HLA IgG. The binding of these alloantibodies to donor platelets can result in rapid clearance after transfusion, presumably via FcγR-mediated phagocytosis and/or complement activation, which both are affected by the IgG-Fc glycosylation.<h4>Objectives</h4>To characterize the Fc glycosylation profile of anti-HLA class I antibodies formeJournal of thrombosis and haemostasis : JTHAltered Fc glycosylation of anti-HLA alloantibodies in hemato-oncological patients receiving platelet transfusions.PMC98285022282Geerdes DMPongracz TVidarsson GKerkhoffs JHde Haas MWuhrer Mvan Osch TLJKapur RMok JYPorcelijn Lvan der Meer PFVoorberg Jvan der Schoot CEvan Esch WJEfalseAltered Fc glycosylation of anti-HLA alloantibodies in hemato-oncological patients receiving platelet transfusions.<h4>Background</h4>The formation of alloantibodies directed against class I human leukocyte antigens (HLA) continues to be a clinically challenging complication after platelet transfusions, which can lead to platelet refractoriness (PR) and occurs in approximately 5%-15% of patients with chronic platelet support. Interestingly, anti-HLA IgG levels in alloimmunized patients do not seem to predict PR, suggesting functional or qualitative differences among anti-HLA IgG. The binding of these alloantibodies to donor platelets can result in rapid clearance after transfusion, presumably via FcγR-mediated phagocytosis and/or complement activation, which both are affected by the IgG-Fc glycosylation.<h4>Objectives</h4>To characterize the Fc glycosylation profile of anti-HLA class I antibodies forme2022-01-01T00:00:00Z2022 Dec2025-04-21T17:58:35.383Z2025-04-05T17:02:34.429ZS-EPMC98285023616564210.1111/jth.15898