{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(12)"],"submitter":["Favaloro EJ"],"funding":["NSW Health Pathology"],"pubmed_abstract":["<h4>Background</h4>Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare complication of adenovirus-based vaccines aimed to prevent and minimize COVID-19 and related pathophysiology.<h4>Objectives</h4>To describe patterns of testing for anti-platelet factor 4 (PF4) antibodies using various ELISA assays in a large Australian cohort and comparative functional platelet activation assays in a subset.<h4>Patients/methods</h4>Asserachrom HPIA IgG ELISA was performed in 1284 patients over a period of 12 months, supplemented in select cohorts by comparative ELISA using three other methods (n = 78-179), three different functional assays (flow cytometry, serotonin release assay, and/or Multiplate; n = 476), and rapid immunological chemiluminescence anti-PF4 assay (n = 460), in a multicenter s"],"journal":["Journal of thrombosis and haemostasis : JTH"],"pagination":["2896-2908"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9828670"],"repository":["biostudies-literature"],"pubmed_title":["Assessment of immunological anti-platelet factor 4 antibodies for vaccine-induced thrombotic thrombocytopenia (VITT) in a large Australian cohort: A multicenter study comprising 1284 patients."],"pmcid":["PMC9828670"],"pubmed_authors":["Favaloro EJ","Pepperell D","Fu S","Clifford J","Leitinger E","Tohidi-Esfahani I","Clarke L","Parker M","Chen VM","Tan CW","Gardiner EE","Yacoub O","Bird R","Kaminskis L","Passam F","Ho SJ","Brighton T","Kershaw G","Duncan E","Sung P","Ballard L","Young-Ill Choi P","Chunilal S","Tran H","Lee CSM","Modica N","Ahuja M"],"additional_accession":[]},"is_claimable":false,"name":"Assessment of immunological anti-platelet factor 4 antibodies for vaccine-induced thrombotic thrombocytopenia (VITT) in a large Australian cohort: A multicenter study comprising 1284 patients.","description":"<h4>Background</h4>Vaccine-induced thrombotic thrombocytopenia (VITT) is a rare complication of adenovirus-based vaccines aimed to prevent and minimize COVID-19 and related pathophysiology.<h4>Objectives</h4>To describe patterns of testing for anti-platelet factor 4 (PF4) antibodies using various ELISA assays in a large Australian cohort and comparative functional platelet activation assays in a subset.<h4>Patients/methods</h4>Asserachrom HPIA IgG ELISA was performed in 1284 patients over a period of 12 months, supplemented in select cohorts by comparative ELISA using three other methods (n = 78-179), three different functional assays (flow cytometry, serotonin release assay, and/or Multiplate; n = 476), and rapid immunological chemiluminescence anti-PF4 assay (n = 460), in a multicenter s","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-19T13:33:52.962Z","creation":"2025-04-19T13:33:52.962Z"},"accession":"S-EPMC9828670","cross_references":{"pubmed":["36107495"],"doi":["10.1111/jth.15881"]}}