{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ansmann N"],"funding":["Deutsche Forschungsgemeinschaft","DFG"],"pagination":["e202210132"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9828832"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(44)"],"pubmed_abstract":["The Lewis superacid bis(perchlorocatecholato)silane catalyzes C-O bond metathesis of alkyl ethers with an efficiency outperforming all earlier reported systems. Chemoselective ring contractions of macrocyclic crown ethers enable substrate-specific transformations, and an unprecedented ring-closing metathesis of polyethylene glycols allows polymer-selective degradation. Quantum chemical computations scrutinize a high Lewis acidity paired with a simultaneous low propensity for polydentate substrate binding as critical for successful catalysis. Based on these mechanistic insights, a second-generation class of silicon Lewis superacid with enhanced efficacy is identified and demonstrated."],"journal":["Angewandte Chemie (International ed. in English)"],"pubmed_title":["Silicon Catalyzed C-O Bond Ring Closing Metathesis of Polyethers."],"pmcid":["PMC9828832"],"funding_grant_id":["GR5007/2-1"],"pubmed_authors":["Ansmann N","Greb L","Thorwart T"],"additional_accession":[]},"is_claimable":false,"name":"Silicon Catalyzed C-O Bond Ring Closing Metathesis of Polyethers.","description":"The Lewis superacid bis(perchlorocatecholato)silane catalyzes C-O bond metathesis of alkyl ethers with an efficiency outperforming all earlier reported systems. Chemoselective ring contractions of macrocyclic crown ethers enable substrate-specific transformations, and an unprecedented ring-closing metathesis of polyethylene glycols allows polymer-selective degradation. Quantum chemical computations scrutinize a high Lewis acidity paired with a simultaneous low propensity for polydentate substrate binding as critical for successful catalysis. Based on these mechanistic insights, a second-generation class of silicon Lewis superacid with enhanced efficacy is identified and demonstrated.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-03-17T15:46:11.055Z","creation":"2025-04-19T23:09:52.412Z"},"accession":"S-EPMC9828832","cross_references":{"pubmed":["36106685"],"doi":["10.1002/anie.202210132"]}}