{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rufai SR"],"funding":["Great Ormond Street Hospital Childrens Charity","National Institute for Health Research (NIHR)"],"pagination":["139-145"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9829653"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(1)"],"pubmed_abstract":["<h4>Aims</h4>To assess the diagnostic accuracy of fundoscopy and visual evoked potentials (VEPs) in detecting intracranial hypertension (IH) in patients with craniosynostosis undergoing spring-assisted posterior vault expansion (sPVE).<h4>Methods</h4>Children with craniosynostosis undergoing sPVE and 48-hour intracranial pressure (ICP) monitoring were included in this single-centre, retrospective, diagnostic accuracy study. Data for ICP, fundoscopy and VEPs were analysed. Primary outcome measures were papilloedema on fundoscopy, VEP assessments and IH, defined as mean ICP > 20 mmHg. Diagnostic indices were calculated for fundoscopy and VEPs against IH. Secondary outcome measures included final visual outcomes.<h4>Results</h4>Fundoscopic examinations were available for 35 children and isola"],"journal":["Eye (London, England)"],"pubmed_title":["Electrophysiological and fundoscopic detection of intracranial hypertension in craniosynostosis."],"pmcid":["PMC9829653"],"funding_grant_id":["W1037","NIHR300155","NIHR 300155 Doctoral Fellowship Award"],"pubmed_authors":["Gottlob I","van de Lande LS","Proudlock FA","Marmoy OR","Breakey RW","Hayward R","Mohamed S","Schwiebert K","Panteli V","Rufai SR","Thompson DA","Bowman R","Bunce C","Dunaway DJ","Jeelani NUO"],"additional_accession":[]},"is_claimable":false,"name":"Electrophysiological and fundoscopic detection of intracranial hypertension in craniosynostosis.","description":"<h4>Aims</h4>To assess the diagnostic accuracy of fundoscopy and visual evoked potentials (VEPs) in detecting intracranial hypertension (IH) in patients with craniosynostosis undergoing spring-assisted posterior vault expansion (sPVE).<h4>Methods</h4>Children with craniosynostosis undergoing sPVE and 48-hour intracranial pressure (ICP) monitoring were included in this single-centre, retrospective, diagnostic accuracy study. Data for ICP, fundoscopy and VEPs were analysed. Primary outcome measures were papilloedema on fundoscopy, VEP assessments and IH, defined as mean ICP > 20 mmHg. Diagnostic indices were calculated for fundoscopy and VEPs against IH. Secondary outcome measures included final visual outcomes.<h4>Results</h4>Fundoscopic examinations were available for 35 children and isola","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-05-29T16:17:38.215Z","creation":"2025-04-19T23:07:26.864Z"},"accession":"S-EPMC9829653","cross_references":{"pubmed":["34974540"],"doi":["10.1038/s41433-021-01839-w"]}}