biostudies-literatureRufai SRGreat Ormond Street Hospital Childrens CharityNational Institute for Health Research (NIHR)139-145https://www.ebi.ac.uk/biostudies/studies/S-EPMC9829653biostudies-literatureUnknown37(1)<h4>Aims</h4>To assess the diagnostic accuracy of fundoscopy and visual evoked potentials (VEPs) in detecting intracranial hypertension (IH) in patients with craniosynostosis undergoing spring-assisted posterior vault expansion (sPVE).<h4>Methods</h4>Children with craniosynostosis undergoing sPVE and 48-hour intracranial pressure (ICP) monitoring were included in this single-centre, retrospective, diagnostic accuracy study. Data for ICP, fundoscopy and VEPs were analysed. Primary outcome measures were papilloedema on fundoscopy, VEP assessments and IH, defined as mean ICP > 20 mmHg. Diagnostic indices were calculated for fundoscopy and VEPs against IH. Secondary outcome measures included final visual outcomes.<h4>Results</h4>Fundoscopic examinations were available for 35 children and isolaEye (London, England)Electrophysiological and fundoscopic detection of intracranial hypertension in craniosynostosis.PMC9829653W1037NIHR300155NIHR 300155 Doctoral Fellowship AwardGottlob Ivan de Lande LSProudlock FAMarmoy ORBreakey RWHayward RMohamed SSchwiebert KPanteli VRufai SRThompson DABowman RBunce CDunaway DJJeelani NUOfalseElectrophysiological and fundoscopic detection of intracranial hypertension in craniosynostosis.<h4>Aims</h4>To assess the diagnostic accuracy of fundoscopy and visual evoked potentials (VEPs) in detecting intracranial hypertension (IH) in patients with craniosynostosis undergoing spring-assisted posterior vault expansion (sPVE).<h4>Methods</h4>Children with craniosynostosis undergoing sPVE and 48-hour intracranial pressure (ICP) monitoring were included in this single-centre, retrospective, diagnostic accuracy study. Data for ICP, fundoscopy and VEPs were analysed. Primary outcome measures were papilloedema on fundoscopy, VEP assessments and IH, defined as mean ICP > 20 mmHg. Diagnostic indices were calculated for fundoscopy and VEPs against IH. Secondary outcome measures included final visual outcomes.<h4>Results</h4>Fundoscopic examinations were available for 35 children and isola2023-01-01T00:00:00Z2023 Jan2025-05-29T16:17:38.215Z2025-04-19T23:07:26.864ZS-EPMC98296533497454010.1038/s41433-021-01839-w