biostudies-literatureUnknown4(5)Lee C<h4>Background</h4>The use of immune checkpoint inhibitors (ICI) is associated with cardiovascular (CV) events, and patients with pre-existing autoimmune disease are at increased CV risk.<h4>Objectives</h4>The aim of this study was to characterize the risk for CV events in patients with pre-existing autoimmune disease post-ICI.<h4>Methods</h4>This was a retrospective study of 6,683 patients treated with ICIs within an academic network. Autoimmune disease prior to ICI was confirmed by chart review. Baseline characteristics and risk for CV and non-CV immune-related adverse events were compared with a matched control group (1:1 ratio) of ICI patients without autoimmune disease. Matching was based on age, sex, history of coronary artery disease, history of heart failure, and diabetes mellitus.JACC. CardioOncology660-669https://www.ebi.ac.uk/biostudies/studies/S-EPMC9830202biostudies-literaturePre-Existing Autoimmune Disease Increases the Risk of Cardiovascular and Noncardiovascular Events After Immunotherapy.PMC9830202Taron JHoffmann UReynolds KLMayrhofer TSchoenfeld SGongora CAZhang LFaje ADrobni ZDRambarat PKLee CAlvi RMZafar AGilman HKMurphy SPHartmann SEMosarla RCZlotoff DASullivan RJRaghu VKNeilan TGfalsePre-Existing Autoimmune Disease Increases the Risk of Cardiovascular and Noncardiovascular Events After Immunotherapy.<h4>Background</h4>The use of immune checkpoint inhibitors (ICI) is associated with cardiovascular (CV) events, and patients with pre-existing autoimmune disease are at increased CV risk.<h4>Objectives</h4>The aim of this study was to characterize the risk for CV events in patients with pre-existing autoimmune disease post-ICI.<h4>Methods</h4>This was a retrospective study of 6,683 patients treated with ICIs within an academic network. Autoimmune disease prior to ICI was confirmed by chart review. Baseline characteristics and risk for CV and non-CV immune-related adverse events were compared with a matched control group (1:1 ratio) of ICI patients without autoimmune disease. Matching was based on age, sex, history of coronary artery disease, history of heart failure, and diabetes mellitus.2022-01-01T00:00:00Z2022 Dec2025-04-04T07:21:04.524Z2025-04-04T07:21:04.524ZS-EPMC98302023663644310.1016/j.jaccao.2022.11.008