biostudies-literatureUnknown13(6)Guo W<h4>Background</h4>Pancreatic cancer has a high degree of malignancy and high mortality. Understanding its biological status can provide more therapeutic targets for the future. The present study was to investigate whether curcumin can inhibit pancreatic cancer cell proliferation by regulating Beclin1 expression and inhibiting the hypoxia-inducible factor-1α (<i>HIF-1α</i>)-mediated glycolytic pathway.<h4>Methods</h4>Two pancreatic cancer cell lines, PANC-1 and SW1990, were treated with different concentrations of curcumin (0, 20, 40, and 60 µM). Cell viability was detected using the Cell Counting Kit-8 (CCK-8) assay and flow cytometry was performed to determine the apoptosis rate and cell cycle arrest of the pancreatic cancer cells. PANC-1 and SW1990 cells were treated with different concJournal of gastrointestinal oncology3254-3262https://www.ebi.ac.uk/biostudies/studies/S-EPMC9830349biostudies-literatureCurcumin inhibits pancreatic cancer cell proliferation by regulating Beclin1 expression and inhibiting the hypoxia-inducible factor-1α-mediated glycolytic pathway.PMC9830349Ding YJin XGuo WWang ZDeng WPu CfalseCurcumin inhibits pancreatic cancer cell proliferation by regulating Beclin1 expression and inhibiting the hypoxia-inducible factor-1α-mediated glycolytic pathway.<h4>Background</h4>Pancreatic cancer has a high degree of malignancy and high mortality. Understanding its biological status can provide more therapeutic targets for the future. The present study was to investigate whether curcumin can inhibit pancreatic cancer cell proliferation by regulating Beclin1 expression and inhibiting the hypoxia-inducible factor-1α (<i>HIF-1α</i>)-mediated glycolytic pathway.<h4>Methods</h4>Two pancreatic cancer cell lines, PANC-1 and SW1990, were treated with different concentrations of curcumin (0, 20, 40, and 60 µM). Cell viability was detected using the Cell Counting Kit-8 (CCK-8) assay and flow cytometry was performed to determine the apoptosis rate and cell cycle arrest of the pancreatic cancer cells. PANC-1 and SW1990 cells were treated with different conc2022-01-01T00:00:00Z2022 Dec2025-04-04T07:21:40.414Z2025-04-04T07:21:40.414ZS-EPMC98303493663605810.21037/jgo-22-802