{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(2)"],"submitter":["Yang H"],"pubmed_abstract":["<b>Rationale:</b> Conventional <sup>18</sup>F-labeling methods that demand substrate pre-modification or lengthy radiosynthesis procedures have impeded the visualization and translation of numerous biomolecules, as biomarkers or ligands, using modern positron emission tomography techniques <i>in vivo</i>. Moreover, <sup>18</sup>F-labeled biomolecules in high molar activity (A<sub>m</sub>) that are indispensable for sensitive imaging could be only achieved under strict labeling conditions. <b>Methods:</b> Herein, <sup>18</sup>F-labeled fluorothiophosphate (FTP) synthons in high A<sub>m</sub> have been generated rapidly <i>in situ</i> in reaction solutions with < 5% water <i>via</i> nucleophilic substitution by wet [<sup>18</sup>F]F<sup>-</sup>, which required minimal processing from cyclotr"],"journal":["Theranostics"],"pagination":["472-482"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9830440"],"repository":["biostudies-literature"],"pubmed_title":["Simplified one-pot <sup>18</sup>F-labeling of biomolecules with <i>in situ</i> generated fluorothiophosphate synthons in high molar activity."],"pmcid":["PMC9830440"],"pubmed_authors":["Yang H","Liu H","He F","Li J","Li Z","Zhang Y","Zhang L","Chen X","Mou Z"],"additional_accession":[]},"is_claimable":false,"name":"Simplified one-pot <sup>18</sup>F-labeling of biomolecules with <i>in situ</i> generated fluorothiophosphate synthons in high molar activity.","description":"<b>Rationale:</b> Conventional <sup>18</sup>F-labeling methods that demand substrate pre-modification or lengthy radiosynthesis procedures have impeded the visualization and translation of numerous biomolecules, as biomarkers or ligands, using modern positron emission tomography techniques <i>in vivo</i>. Moreover, <sup>18</sup>F-labeled biomolecules in high molar activity (A<sub>m</sub>) that are indispensable for sensitive imaging could be only achieved under strict labeling conditions. <b>Methods:</b> Herein, <sup>18</sup>F-labeled fluorothiophosphate (FTP) synthons in high A<sub>m</sub> have been generated rapidly <i>in situ</i> in reaction solutions with < 5% water <i>via</i> nucleophilic substitution by wet [<sup>18</sup>F]F<sup>-</sup>, which required minimal processing from cyclotr","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T21:55:05.198Z","creation":"2025-02-18T23:36:59.988Z"},"accession":"S-EPMC9830440","cross_references":{"pubmed":["36632226"],"doi":["10.7150/thno.79452"]}}