{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(2)"],"submitter":["Wang L"],"pubmed_abstract":["<b>Background:</b> Synthetic hydrogels are commonly mechanically weak which limits the scope of their applications. <b>Methods:</b> In this study, we synthesized an organic-inorganic hybrid hydrogel with ultrahigh strength, stiffness, and toughness via enzyme-induced mineralization of calcium phosphate in a double network of bacterial cellulose nanofibers and alginate-Ca<sup>2+</sup>. <b>Results:</b> Cellulose nanofibers formed the first rigid network via hydrogen binding and templated the deposition of calcium phosphate, while alginate-Ca<sup>2+</sup> formed the second energy-dissipating network via ionic interaction. The two networks created a brick-mortar-like structure, in which the \"tortuous fracture path\" mechanism by breaking the interlaced calcium phosphate-coated bacterial cellulo"],"journal":["Theranostics"],"pagination":["673-684"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9830447"],"repository":["biostudies-literature"],"pubmed_title":["Enzymatically-mineralized double-network hydrogels with ultrahigh mechanical strength, toughness, and stiffness."],"pmcid":["PMC9830447"],"pubmed_authors":["Li W","Zhao W","Wang G","Zhao Y","Zhang Q","Wang L"],"additional_accession":[]},"is_claimable":false,"name":"Enzymatically-mineralized double-network hydrogels with ultrahigh mechanical strength, toughness, and stiffness.","description":"<b>Background:</b> Synthetic hydrogels are commonly mechanically weak which limits the scope of their applications. <b>Methods:</b> In this study, we synthesized an organic-inorganic hybrid hydrogel with ultrahigh strength, stiffness, and toughness via enzyme-induced mineralization of calcium phosphate in a double network of bacterial cellulose nanofibers and alginate-Ca<sup>2+</sup>. <b>Results:</b> Cellulose nanofibers formed the first rigid network via hydrogen binding and templated the deposition of calcium phosphate, while alginate-Ca<sup>2+</sup> formed the second energy-dissipating network via ionic interaction. The two networks created a brick-mortar-like structure, in which the \"tortuous fracture path\" mechanism by breaking the interlaced calcium phosphate-coated bacterial cellulo","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-04T21:55:04.148Z","creation":"2025-02-18T23:37:05.913Z"},"accession":"S-EPMC9830447","cross_references":{"pubmed":["36632214"],"doi":["10.7150/thno.77417"]}}