{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen J"],"funding":["CIHR"],"pagination":["610-624"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9830508"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(2)"],"pubmed_abstract":["Emerging observational data suggest that vitamin D deficiency is associated with the onset and progression of knee osteoarthritis (OA). However, the relationship between vitamin D level and OA and the role of vitamin D supplementation in the prevention of knee OA are controversial. To address these issues, we analyzed the articular cartilage phenotype of 6- and 12-month-old wild-type and 1α(OH)ase<sup>-/-</sup> mice and found that 1,25(OH)<sub>2</sub>D deficiency accelerated the development of age-related spontaneous knee OA, including cartilage surface destruction, cartilage erosion, proteoglycan loss and cytopenia, increased OARSI score, collagen X and Mmp13 positive chondrocytes, and increased chondrocyte senescence with senescence-associated secretory phenotype (SASP). 1,25(OH)<sub>2</"],"journal":["International journal of biological sciences"],"pubmed_title":["1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice."],"pmcid":["PMC9830508"],"funding_grant_id":["PJT-152963"],"pubmed_authors":["Li J","Lu N","Miao D","Chen J","Zhang J","Yang R","Goltzman D","Qin R"],"additional_accession":[]},"is_claimable":false,"name":"1,25-Dihydroxyvitamin D Deficiency Accelerates Aging-related Osteoarthritis via Downregulation of Sirt1 in Mice.","description":"Emerging observational data suggest that vitamin D deficiency is associated with the onset and progression of knee osteoarthritis (OA). However, the relationship between vitamin D level and OA and the role of vitamin D supplementation in the prevention of knee OA are controversial. To address these issues, we analyzed the articular cartilage phenotype of 6- and 12-month-old wild-type and 1α(OH)ase<sup>-/-</sup> mice and found that 1,25(OH)<sub>2</sub>D deficiency accelerated the development of age-related spontaneous knee OA, including cartilage surface destruction, cartilage erosion, proteoglycan loss and cytopenia, increased OARSI score, collagen X and Mmp13 positive chondrocytes, and increased chondrocyte senescence with senescence-associated secretory phenotype (SASP). 1,25(OH)<sub>2</","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023","modification":"2025-04-26T06:04:07.882Z","creation":"2025-04-06T11:42:34.469Z"},"accession":"S-EPMC9830508","cross_references":{"pubmed":["36632467"],"doi":["10.7150/ijbs.78785"]}}