{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hsueh BY"],"funding":["NIAID NIH HHS","Michigan State University","U.S. Department of Health & Human Services | National Institutes of Health","NIGMS NIH HHS","National Science Foundation"],"pagination":["1210-1220"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9830645"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(8)"],"pubmed_abstract":["Vibrio cholerae biotype El Tor is perpetuating the longest cholera pandemic in recorded history. The genomic islands VSP-1 and VSP-2 distinguish El Tor from previous pandemic V. cholerae strains. Using a co-occurrence analysis of VSP genes in >200,000 bacterial genomes we built gene networks to infer biological functions encoded in these islands. This revealed that dncV, a component of the cyclic-oligonucleotide-based anti-phage signalling system (CBASS) anti-phage defence system, co-occurs with an uncharacterized gene vc0175 that we rename avcD for anti-viral cytodine deaminase. We show that AvcD is a deoxycytidylate deaminase and that its activity is post-translationally inhibited by a non-coding RNA named AvcI. AvcID and bacterial homologues protect bacterial populations against phage i"],"journal":["Nature microbiology"],"pubmed_title":["Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria."],"pmcid":["PMC9830645"],"funding_grant_id":["AI143098","R41 AI143098","R35 GM139537","R01 GM110444","GM109259","R01 GM110185","R01 AI158433","GM139537","GM110444","1842399","R01 GM109259","AI158433","DBI-0939454","GM110185","1750125"],"pubmed_authors":["Elg CA","Neiditch MB","Hsueh BY","Parent KN","Ridenhour BJ","Top EM","Waters CM","Severin GB","Wessel AJ","Ravi J","Kant A","Dover JA","Waldron EJ","Rhoades CR"],"additional_accession":[]},"is_claimable":false,"name":"Phage defence by deaminase-mediated depletion of deoxynucleotides in bacteria.","description":"Vibrio cholerae biotype El Tor is perpetuating the longest cholera pandemic in recorded history. The genomic islands VSP-1 and VSP-2 distinguish El Tor from previous pandemic V. cholerae strains. Using a co-occurrence analysis of VSP genes in >200,000 bacterial genomes we built gene networks to infer biological functions encoded in these islands. This revealed that dncV, a component of the cyclic-oligonucleotide-based anti-phage signalling system (CBASS) anti-phage defence system, co-occurs with an uncharacterized gene vc0175 that we rename avcD for anti-viral cytodine deaminase. We show that AvcD is a deoxycytidylate deaminase and that its activity is post-translationally inhibited by a non-coding RNA named AvcI. AvcID and bacterial homologues protect bacterial populations against phage i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-06-04T05:49:38.779Z","creation":"2025-04-19T13:31:48.829Z"},"accession":"S-EPMC9830645","cross_references":{"pubmed":["35817890"],"doi":["10.1038/s41564-022-01162-4"]}}