{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ali WAS"],"funding":["Guangdong Basic and Applied Basic Research Foundation","National Nature Science Foundation of China"],"pagination":["10732748221148912"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9830708"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["30"],"pubmed_abstract":["<h4>Background</h4>We aimed to investigate the determinant factors of anti-PD-1 therapy outcome in nasopharyngeal carcinoma (NPC).<h4>Methods</h4>In this retrospective study, we included 64 patients with recurrent/metastatic NPC. The association of patients' characteristics, C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), and lactate dehydrogenase (LDH) with survival benefit of anti-PD-1 therapy were analyzed using Cox regression models and Kaplan-Meier analyses. Patients were divided based on the median value of CRP, NLR or LDH into different subgroups.<h4>Results</h4>At a median follow-up time of 11.4 months (range: 1-28 months), median progression-free survival (PFS) and overall survival (OS) were 1.9 months (95% CI, .18-3.6) and 15 months (95% CI, 10.9-19.1) months, res"],"journal":["Cancer control : journal of the Moffitt Cancer Center"],"pubmed_title":["Pretreatment Serum Lactate Dehydrogenase and Metastases Numbers as Potential Determinants of Anti-PD-1 Therapy Outcome in Nasopharyngeal Carcinoma."],"pmcid":["PMC9830708"],"funding_grant_id":["82002409, 81872201, 81872499","2020A1515010020, 2018A0303130243"],"pubmed_authors":["Ma Y","Zhang L","Zhao Y","Ali WAS","Pan H","Liao J","Yang Z","Yang Y","Huang Y","Fang W","Huang X","Wu Y","Hong S","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Pretreatment Serum Lactate Dehydrogenase and Metastases Numbers as Potential Determinants of Anti-PD-1 Therapy Outcome in Nasopharyngeal Carcinoma.","description":"<h4>Background</h4>We aimed to investigate the determinant factors of anti-PD-1 therapy outcome in nasopharyngeal carcinoma (NPC).<h4>Methods</h4>In this retrospective study, we included 64 patients with recurrent/metastatic NPC. The association of patients' characteristics, C-reactive protein (CRP), neutrophil to lymphocyte ratio (NLR), and lactate dehydrogenase (LDH) with survival benefit of anti-PD-1 therapy were analyzed using Cox regression models and Kaplan-Meier analyses. Patients were divided based on the median value of CRP, NLR or LDH into different subgroups.<h4>Results</h4>At a median follow-up time of 11.4 months (range: 1-28 months), median progression-free survival (PFS) and overall survival (OS) were 1.9 months (95% CI, .18-3.6) and 15 months (95% CI, 10.9-19.1) months, res","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan-Dec","modification":"2026-05-27T23:13:51.58Z","creation":"2024-11-20T14:29:23.314Z"},"accession":"S-EPMC9830708","cross_references":{"pubmed":["36592162"],"doi":["10.1177/10732748221148912"]}}