{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duell AK"],"funding":["National Institute of Environmental Health Sciences","NIEHS NIH HHS","Food and Drug Administration"],"pagination":["1241-1249"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9831380"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(6)"],"pubmed_abstract":["Electronic cigarette liquids (e-liquids) with sweetener additives such as sucralose, a synthetic chlorinated disaccharide, are popular among some e-cigarette consumers; sucralose can be added either by the manufacturer or by the consumer. The prevalence of sucralose in commercial e-liquids is not known, nor is the typical concentration of sucralose when present; labels are not required to disclose ingredient information. Here, we report the effects of sucralose on e-liquid degradation upon e-cigarette vaping as studied using <sup>1</sup>H NMR spectroscopy, ion chromatography, and gas chromatography coupled with detection by mass spectrometry or flame ionization detector. Sucralose was found to be subject to degradation when included in propylene glycol + glycerol based e-liquids and vaped; the presence of sucralose in the e-liquids also resulted in altered and enhanced solvent degradation. In particular, production of aldehydes (carbonyls) and hemiacetals (which have implications for health) was enhanced, as demonstrated by <sup>1</sup>H NMR. The presence of sucralose at 0.03 mol % (0.14 wt %) in an e-liquid also resulted in production of potentially harmful organochlorine compounds and catalyzed the cyclization of aldehydes with solvents to acetals upon vaping; the presence of chloride in e-liquid aerosols was confirmed by ion chromatography. Quantities of sucralose as low as 0.05 mol % (0.24 wt %) in e-liquids lead to significant production of solvent degradation products."],"journal":["Chemical research in toxicology"],"pubmed_title":["Sucralose-Enhanced Degradation of Electronic Cigarette Liquids during Vaping."],"pmcid":["PMC9831380"],"funding_grant_id":["R01 ES025257","R01ES025257"],"pubmed_authors":["Duell AK","McWhirter KJ","Peyton DH","Korzun T","Strongin RM"],"additional_accession":[]},"is_claimable":false,"name":"Sucralose-Enhanced Degradation of Electronic Cigarette Liquids during Vaping.","description":"Electronic cigarette liquids (e-liquids) with sweetener additives such as sucralose, a synthetic chlorinated disaccharide, are popular among some e-cigarette consumers; sucralose can be added either by the manufacturer or by the consumer. The prevalence of sucralose in commercial e-liquids is not known, nor is the typical concentration of sucralose when present; labels are not required to disclose ingredient information. Here, we report the effects of sucralose on e-liquid degradation upon e-cigarette vaping as studied using <sup>1</sup>H NMR spectroscopy, ion chromatography, and gas chromatography coupled with detection by mass spectrometry or flame ionization detector. Sucralose was found to be subject to degradation when included in propylene glycol + glycerol based e-liquids and vaped; the presence of sucralose in the e-liquids also resulted in altered and enhanced solvent degradation. In particular, production of aldehydes (carbonyls) and hemiacetals (which have implications for health) was enhanced, as demonstrated by <sup>1</sup>H NMR. The presence of sucralose at 0.03 mol % (0.14 wt %) in an e-liquid also resulted in production of potentially harmful organochlorine compounds and catalyzed the cyclization of aldehydes with solvents to acetals upon vaping; the presence of chloride in e-liquid aerosols was confirmed by ion chromatography. Quantities of sucralose as low as 0.05 mol % (0.24 wt %) in e-liquids lead to significant production of solvent degradation products.","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Jun","modification":"2026-03-17T15:42:27.261Z","creation":"2025-04-19T23:06:36.299Z"},"accession":"S-EPMC9831380","cross_references":{"pubmed":["31079450"],"doi":["10.1021/acs.chemrestox.9b00047"]}}