biostudies-literatureUnknown44Du L<h4>Background and aims</h4>The role of <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection in carotid atherosclerosis remains inconsistent and sometimes controversial. We aimed to determine whether <i>H. pylori</i> infection is associated with carotid atherosclerotic plaques in a large number of Chinese adults.<h4>Methods</h4>We recruited 108,210 Chinese adults who participated in a standard medical screening with both carotid ultrasonic examination and ¹³C-urea breath test for <i>H.pylori</i> infection from two Chinese cohorts. A total of 93,915 adults were included in the analysis after excluding participants with cardiovascular disease (CVD) and carotid plaques at baseline. Hazard ratio (HR) for developing carotid plaques by <i>H. pylori</i> infection was analyzed using Atherosclerosis plus25-30https://www.ebi.ac.uk/biostudies/studies/S-EPMC9833265biostudies-literatureAssociation between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults.PMC9833265Liu JLi SJin CMan SZhang XNing YMa YDu LYin LLi LfalseAssociation between Helicobacter pylori infection and carotid atherosclerosis in Chinese adults.<h4>Background and aims</h4>The role of <i>Helicobacter pylori</i> (<i>H. pylori</i>) infection in carotid atherosclerosis remains inconsistent and sometimes controversial. We aimed to determine whether <i>H. pylori</i> infection is associated with carotid atherosclerotic plaques in a large number of Chinese adults.<h4>Methods</h4>We recruited 108,210 Chinese adults who participated in a standard medical screening with both carotid ultrasonic examination and ¹³C-urea breath test for <i>H.pylori</i> infection from two Chinese cohorts. A total of 93,915 adults were included in the analysis after excluding participants with cardiovascular disease (CVD) and carotid plaques at baseline. Hazard ratio (HR) for developing carotid plaques by <i>H. pylori</i> infection was analyzed using 2021-01-01T00:00:00Z2021 Oct2025-04-18T13:25:28.926Z2025-04-06T23:04:33.413ZS-EPMC98332653664466610.1016/j.athplu.2021.08.004